ArticlePloS one2012
Identification of maize genes associated with host plant resistance or susceptibility to Aspergillus flavus infection and aflatoxin accumulation.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 76 citations in OpenAlex.
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- Host-Induced Gene Silencing of theToxins · 2024Article
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- Food Safety Aspects of Breeding Maize to Multi-Resistance against the MajorJournal of fungi (Basel, Switzerland) · 2024Review
- The Glycine-Rich RNA-Binding Protein Is a Vital Post-Transcriptional Regulator in Crops.Plants (Basel, Switzerland) · 2023Review
- Comprehensive meta-analysis of QTL and gene expression studies identify candidate genes associated withFrontiers in plant science · 2023Article
- Set2 family regulates mycotoxin metabolism and virulence via H3K36 methylation in pathogenic fungusVirulence · 2022Article
- Role of Tocochromanols in Tolerance of Cereals to Biotic Stresses: Specific Focus on Pathogenic and Toxigenic Fungal Species.International journal of molecular sciences · 2022Review
- Comparative transcriptome profiling and weighted gene co-expression network analysis to identify core genes in maize (Frontiers in plant science · 2022Article
- Marine Macroalgae, a Source of Natural Inhibitors of Fungal Phytopathogens.Journal of fungi (Basel, Switzerland) · 2021Review
- Roles of Plant Glycine-Rich RNA-Binding Proteins in Development and Stress Responses.International journal of molecular sciences · 2021Review
- Comparative transcriptome profiling and co-expression network analysis uncover the key genes associated withearly-stage resistance to Aspergillus flavus in maize.BMC plant biology · 2021Article
- Effectors of Plant Necrotrophic Fungi.Frontiers in plant science · 2021Review
- Flavonoids Modulate the Accumulation of Toxins FromFrontiers in plant science · 2021Article
- Genome-wide association study leads to novel genetic insights into resistance to Aspergillus flavus in maize kernels.BMC plant biology · 2020Article
- Mapping Quantitative Trait Loci Associated With Resistance to Aflatoxin Accumulation in Maize Inbred Mp719.Frontiers in microbiology · 2020Article
- Functional Biology and Molecular Mechanisms of Host-Pathogen Interactions for Aflatoxin Contamination in Groundnut (Frontiers in microbiology · 2020Review
- TheFrontiers in microbiology · 2019Review
- Differential Expression of Signaling Pathway Genes Associated With Aflatoxin Reduction Quantitative Trait Loci in Maize (Frontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAspergillus flavus infection and aflatoxin contamination of maize pose negative impacts in agriculture and health. Commercial maize hybrids are generally susceptible to this fungus. Significant levels of host plant resistance have been observed in certain maize inbred lines. This study was conducted to identify maize genes associated with host plant resistance or susceptibility to A. flavus infection and aflatoxin accumulation.
resultsGenome wide gene expression levels with or without A. flavus inoculation were compared in two resistant maize inbred lines (Mp313E and Mp04:86) in contrast to two susceptible maize inbred lines (Va35 and B73) by microarray analysis. Principal component analysis (PCA) was used to find genes contributing to the larger variances associated with the resistant or susceptible maize inbred lines. The significance levels of gene expression were determined by using SAS and LIMMA programs. Fifty candidate genes were selected and further investigated by quantitative RT-PCR (qRT-PCR) in a time-course study on Mp313E and Va35. Sixteen of the candidate genes were found to be highly expressed in Mp313E and fifteen in Va35. Out of the 31 highly expressed genes, eight were mapped to seven previously identified quantitative trait locus (QTL) regions. A gene encoding glycine-rich RNA binding protein 2 was found to be associated with the host hypersensitivity and susceptibility in Va35. A nuclear pore complex protein YUP85-like gene was found to be involved in the host resistance in Mp313E.
conclusionMaize genes associated with host plant resistance or susceptibility were identified by a combination of microarray analysis, qRT-PCR analysis, and QTL mapping methods. Our findings suggest that multiple mechanisms are involved in maize host plant defense systems in response to Aspergillus flavus infection and aflatoxin accumulation. These findings will be important in identification of DNA markers for breeding maize lines resistant to aflatoxin accumulation.
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