ArticlePloS one2012
Know your current I(h): interaction with a shunting current explains the puzzling effects of its pharmacological or pathological modulations.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Multimodal evidence for a mechanistic model of working memory deficits in schizophrenia.medRxiv : the preprint server for health sciences · 2026Article
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- Mid-infrared photons relieve tinnitus-like behavior of mice by regulating HCN2 ion channels in the medial geniculate body.Annals of medicine · 2025Article
- Self-organized and self-sustained ensemble activity patterns in simulation of mouse primary motor cortex.bioRxiv : the preprint server for biology · 2025Article
- Review
- Simulations predict differing phase responses to excitation vs. inhibition in theta-resonant pyramidal neurons.Journal of neurophysiology · 2023Article
- Multiscale model of primary motor cortex circuits predicts in vivo cell-type-specific, behavioral state-dependent dynamics.Cell reports · 2023Article
- Different responses of mice and rats hippocampus CA1 pyramidal neurons toFrontiers in cellular neuroscience · 2023Article
- Excitatory and inhibitory effects of HCN channel modulation on excitability of layer V pyramidal cells.PLoS computational biology · 2022Article
- Membrane electrical properties of mouse hippocampal CA1 pyramidal neurons during strong inputs.Biophysical journal · 2022Article
- NeuroGPU: Accelerating multi-compartment, biophysically detailed neuron simulations on GPUs.Journal of neuroscience methods · 2022Article
- IProgress in neuro-psychopharmacology & biological psychiatry · 2022Article
- Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms.Biology · 2022Review
- Ion-channel degeneracy: Multiple ion channels heterogeneously regulate intrinsic physiology of rat hippocampal granule cells.Physiological reports · 2021Article
- Resilience to anhedonia-passive coping induced by early life experience is linked to a long-lasting reduction of INeurobiology of stress · 2021Article
- Effects ofJournal of neurophysiology · 2021Article
- Analysis of Age-Dependent Alterations in Excitability Properties of CA1 Pyramidal Neurons in an APPPS1 Model of Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- Illuminating dendritic function with computational models.Nature reviews. Neuroscience · 2020Review
- Degeneracy in hippocampal physiology and plasticity.Hippocampus · 2019Review
- Bisoprolol, Known to Be a Selective β₁-Receptor Antagonist, Differentially but Directly Suppresses IInternational journal of molecular sciences · 2019Article
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Authors and funding
2 authors.
Funding
Abstract
The non-specific, hyperpolarization activated, I(h) current is particularly involved in epilepsy and it exhibits an excitatory or inhibitory action on synaptic integration in an apparently inconsistent way. It has been suggested that most of the inconsistencies could be reconciled invoking an indirect interaction with the M-type K(+) current, another current involved in epilepsy. However, here we show that the original experiments, and the simplified model used to explain and support them, cannot explain in a conclusive way the puzzling I(h) actions observed in different experimental preparations. Using a realistic model, we show instead how and why a shunting current, such as that carried by TASK-like channels, and dependent on I(h) channel is able to explain virtually all experimental findings on I(h) up- or down-regulation by modulators or pathological conditions. The model results suggest several experimentally testable predictions to characterize in more details this elusive and peculiar interaction, which may be of fundamental importance in the development of new treatments for all those pathological and cognitive dysfunctions caused, mediated, or affected by I(h).
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