Evidence map›Paper›PMID 22606223›Full record

ArticlePloS one2012

A regulatory potential of the Xist gene promoter in vole M. rossiaemeridionalis.

Konstantin E Orishchenko, Sophia V Pavlova, Eugeny A Elisaphenko, Vladimir V Sherstyuk, Alexander V Prinz, Alexander I Shevchenko, Elena V Dementyeva, Suren M Zakian

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Konstantin E OrishchenkoInstitute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, Novosibirsk, Russia.
Sophia V Pavlova
Eugeny A Elisaphenko
Vladimir V Sherstyuk
Alexander V Prinz
Alexander I Shevchenko
Elena V Dementyeva
Suren M Zakian
Institute of Cytology and Genetics · RUInstitute of Chemical Biology and Fundamental Medicine · RUState Research Center of the Russian Federation · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X chromosome inactivation takes place in the early development of female mammals and depends on the Xist gene expression. The mechanisms of Xist expression regulation have not been well understood so far. In this work, we compared Xist promoter region of vole Microtus rossiaemeridionalis and other mammalian species. We observed three conserved regions which were characterized by computational analysis, DNaseI in vitro footprinting, and reporter construct assay. Regulatory factors potentially involved in Xist activation and repression in voles were determined. The role of CpG methylation in vole Xist expression regulation was established. A CTCF binding site was found in the 5' flanking region of the Xist promoter on the active X chromosome in both males and females. We suggest that CTCF acts as an insulator which defines an inactive Xist domain on the active X chromosome in voles.

Indexed as

Promoter Regions, GeneticAnimalsArvicolinaeBase SequenceBinding SitesCCCTC-Binding FactorCell LineDNA MethylationFemaleGene Expression Regulation, DevelopmentalHumansMaleMammalsMolecular Sequence DataRegulatory Elements, TranscriptionalRepressor ProteinsCCCTC-Binding FactorCTCF protein, humanRepressor ProteinsRNA, Long NoncodingRNA, UntranslatedXIST non-coding RNA

Identifiers

PMID22606223
PMCPMC3350511
OpenAlexW2059466533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.