Trial reportTheScientificWorldJournal2012
A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children.
Trial report in TheScientificWorldJournal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05892081 (Effect of Colloidal Oatmeal Compared to Colloid Cream on Diaper Rash Among Preterm Neonates in the Neonatal Intensive Care Unit.), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Colloidal Oatmeal Compared to Colloid Cream on Diaper Rash Among Preterm Neonates in the Neonatal Intensive Care Unit.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review.BMC veterinary research · 2019Pooled it
- Therapeutic management of anal eczema: an evidence-based review.International journal of clinical practice · 2014Pooled it
- Comparing the effects of Bentonite & Calendula on the improvement of infantile diaper dermatitis: A randomized controlled trial.The Indian journal of medical research · 2015Trial
- Comparative Evaluation of Bilateral Cleft Earlobe Rejuvenation with and without Calendula Officinalis 10% V/W- Randomised Control Trial.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Soothing the Itch: The Role of Medicinal Plants in Alleviating Pruritus in Palliative Care.Plants (Basel, Switzerland) · 2024Review
- In Vitro Wound-Healing Potential of Phenolic and Polysaccharide Extracts ofJournal of functional biomaterials · 2024Article
- Review of Malaysian medicinal plants with potential wound healing activity.BMC complementary medicine and therapies · 2024Review
- Current use of medicinal plants for children's diseases among mothers in Southern Romania.Frontiers in pharmacology · 2024Article
- Effects of argan spinosa oil in the treatment of diaper dermatitis in infants and toddlers: A quasi-experimental study.Journal of Taibah University Medical Sciences · 2023Article
- Exploring the Sequential-Selective Supercritical Fluid Extraction (SMolecules (Basel, Switzerland) · 2023Article
- An Updated Review on the Multifaceted Therapeutic Potential ofPharmaceuticals (Basel, Switzerland) · 2023Review
- Article
- A new therapeutic horizon in diaper dermatitis: Novel agents with novel action.International journal of women's dermatology · 2021Review
- Historical ethnobotanical review of medicinal plants used to treat children diseases in Romania (1860s-1970s).Journal of ethnobiology and ethnomedicine · 2020Review
- Wound healing with botanicals: A review and future perspectives.Current dermatology reports · 2018Article
- Noninvasive monitoring of plant-based formulations on skin barrier properties in infants with dry skin and risk for atopic dermatitis.International journal of women's dermatology · 2018Article
- Efficacy of Traditional Medicine Product Henna and Hydrocortisone on Diaper Dermatitis in Infants.Iranian Red Crescent medical journal · 2016Article
- Effect of Topical Application of the Cream Containing Magnesium 2% on Treatment of Diaper Dermatitis and Diaper Rash in Children A Clinical Trial Study.Journal of clinical and diagnostic research : JCDR · 2016Article
- Aloe vera Aqueous Extract Effect on Morphine Withdrawal Syndrome in Morphine-Dependent Female Rats.International journal of high risk behaviors & addiction · 2014Article
- Shampoo-clay heals diaper rash faster than calendula officinalis.Nursing and midwifery studies · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDiaper dermatitis (DD) is a common inflammatory disorder among children and infants. The objective of the present randomized and double-blind trial was to compare the therapeutic efficacies of aloe vera cream and Calendula officinalis ointment on the frequency and severity of DD in children.
methodsSixty-six infants with DD (aged < 3 years) were randomized to receive either aloe cream (n = 32) or Calendula ointment (n = 34). Infants were treated with these drugs 3 times a day for 10 days. The severity of dermatitis was graded at baseline as well as at the end of trial using a 5-point scale. The adverse effects of study medications were assessed during the trial.
resultsAlthough improvement in the severity of DD was observed in both treatment groups (P < 0.001), patients receiving Calendula ointment had significantly fewer rash sites compared to aloe group (P = 0.001). No adverse effect was reported from either of the medications. DISCUSSION: The evidence from this study suggests that topical aloe and in particular Calendula could serve as safe and effective treatment for the treatment of diaper dermatitis in infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.