ArticleTheScientificWorldJournal2012
Vascular function and handgrip strength in rheumatoid arthritis patients.
Article in TheScientificWorldJournal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06387758 (Low Systemic/High Local Exercise Load in Pediatric Sickle Cell Disease), which is not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low Systemic/High Local Exercise Load in Pediatric Sickle Cell Disease
Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Handgrip strength testing in rheumatic diseases.Rheumatology international · 2026Review
- Microvascular endothelial dysfunction in rheumatoid arthritis.Nature reviews. Rheumatology · 2018Review
- Possible Modulation of Vascular Function Measures in Rheumatoid Arthritis by Homocysteine.International journal of rheumatology · 2018Article
- Perceived Versus Performance Fatigability in Patients With Rheumatoid Arthritis.Frontiers in physiology · 2018Review
- Systemic vascular function is associated with muscular power in older adults.Journal of aging research · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the relationship of handgrip strength with forearm blood flow (BF) and vascular resistance (VR) in rheumatoid arthritis (RA) patients.
methodsForearm BF at rest (RBF) and after upper arm occlusion (RHBF), and handgrip strength were examined in 78 individuals (RA = 42 and controls (CT) = 36). Subsequently, VR at rest (RVR) and after occlusion (RHVR) were calculated.
resultsThe patients' RBF (P = 0.02) and RHBF (P = 0.0001) were less, whereas RVR (P = 0.002) and RHVR (P = 0.0001) were greater as compared to the CTs. Similarly, handgrip strength was lower in the RAs (P = 0.0001). Finally, handgrip strength was directly associated with RBF (r = 0.43; P = 0.0001), and RHBF (r = 0.5; P = 0.0001), and inversely related to RVR (r = -0.3; P = 0.009) and RHVR (r = -0.3; P = 0.007).
conclusionThe present study uniquely identifies an association between regional measures of forearm blood flow and handgrip strength in patients and healthy control. In addition, this study confirms the presence of vascular and muscle dysfunction in patients with rheumatoid arthritis, as evidenced by lower forearm blood flow indices, at rest and following occlusion, and lower handgrip strength as compared to healthy individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.