ArticleInternational journal of molecular sciences2012
Salivary proteins associated with periodontitis in patients with Type 2 diabetes mellitus.
Article in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Mass Spectrometry-Based Proteomics for Discovering Salivary Biomarkers in Periodontitis: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Potassium in dental calculus as an indicator of diabetes.BMC oral health · 2026Article
- Salivary gland carbonic anhydrases.Histology and histopathology · 2025Review
- Methodological Development of a Test for Salivary Proteome Analysis Useful in Lung Cancer Screening.International journal of molecular sciences · 2025Article
- Changes in the Protein Profile of Saliva from People with Obesity Treated with Bariatric Surgery and Physical Exercise.International journal of molecular sciences · 2025Article
- Clinical Response Characteristics of Salivary Proteins in the Management Strategy of Diabetes-Associated Periodontitis.Journal of proteome research · 2025Article
- Characterization of Extracellular Vesicle Cargo in Sjögren's Syndrome through a SWATH-MS Proteomics Approach.International journal of molecular sciences · 2021Article
- Proteomics-Based Identification of Salivary Changes in Patients with Burning Mouth Syndrome.Biology · 2021Article
- Label-free quantitative proteomic analysis of gingival crevicular fluid to identify potential early markers for root resorption.BMC oral health · 2020Article
- Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review.Molecules (Basel, Switzerland) · 2020Review
- Changes in Salivary Proteome in Response to Bread Odour.Nutrients · 2020Article
- Preliminary study of the urinary proteome in Li and Han ethnic individuals from Hainan.Science China. Life sciences · 2020Article
- Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases.Disease markers · 2018Review
- Can Saliva Proteins Be Used to Predict the Onset of Acute Myocardial Infarction among High-Risk Patients?International journal of medical sciences · 2015Review
- Uncovering the molecular networks in periodontitis.Proteomics. Clinical applications · 2014Review
- Salivary diagnostics: a brief review.ISRN dentistry · 2014Review
- The landscape of protein biomarkers proposed for periodontal disease: markers with functional meaning.BioMed research international · 2014Review
- Quantitative estimation of sodium, potassium and total protein in saliva of diabetic smokers and nonsmokers: A novel study.Journal of natural science, biology, and medicine · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to investigate the salivary proteins that are associated with periodontitis in patients with Type 2 diabetes mellitus (T2DM). Volunteers for the study were patients from the Diabetic Unit, University of Malaya Medical Centre, whose periodontal status was determined. The diabetic volunteers were divided into two groups, i.e., patients with periodontitis and those who were periodontally healthy. Saliva samples were collected and treated with 10% TCA/acetone/20 mM DTT to precipitate the proteins, which were then separated using two-dimensional polyacrylamide gel electrophoresis. Gel images were scanned using the GS-800(TM) Calibrated Densitometer. The protein spots were analyzed and expressed in percentage volumes. The percentage volume of each protein spot was subjected to Mann-Whitney statistical analysis using SPSS software and false discovery rate correction. When the expression of the salivary proteins was compared between the T2DM patients with periodontitis with those who were periodontally healthy, seven proteins, including polymeric immunoglobulin receptor, plastin-2, actin related protein 3, leukocyte elastase inhibitor, carbonic anhydrases 6, immunoglobulin J and interleukin-1 receptor antagonist, were found to be differentially expressed (p < 0.01304). This implies that the proteins may have the potential to be used as biomarkers for the prediction of T2DM patients who may be prone to periodontitis.
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