ReviewInternational journal of molecular sciences2012
Congenital diarrheal disorders: an updated diagnostic approach.
Review in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06721871 (Evaluation of Safety, Tolerability and Efficacy of Crofelemer Following Multiple Ascending Doses of Crofelemer Powder for Oral Solution in Pediatric Participants With Microvillus Inclusion Disease), which is not on this map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Safety, Tolerability and Efficacy of Crofelemer Following Multiple Ascending Doses of Crofelemer Powder for Oral Solution in Pediatric Participants With Microvillus Inclusion Disease (MVID)
Who cites it
30 citing papers in PubMed.
- Chronic Diarrhoea in Children: The Role of SLC10A2 Gene in Primary Malabsorption of Biliary Acid.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Congenital Diarrhea: A Case Report on Challenges in Both Prenatal and Postnatal Diagnosis.Case reports in obstetrics and gynecology · 2026Article
- Congenital Chloride Diarrhea in Infancy: Unveiling a Rare Clinical Case.Indian pediatrics · 2025Article
- Diet and Management of Diarrhea.Indian journal of pediatrics · 2024Review
- Homozygous Missense Epithelial Cell Adhesion Molecule Variant in a Patient with Congenital Tufting Enteropathy and Literature Review.Pediatric gastroenterology, hepatology & nutrition · 2022Review
- Diagnostic Challenge of Congenital Chloride Diarrhea and Ulcerative Colitis Overlap in an Adult Misdiagnosed with Bartter Syndrome: Case Report and Literature Review.The American journal of case reports · 2022Review
- Microvillus Inclusion Disease: A Rare Mutation of STX3 in Exon 9 Causing Fatal Congenital Diarrheal Disease.Journal of pediatric genetics · 2022Article
- Etiology and Management of Pediatric Intestinal Failure: Focus on the Non-Digestive Causes.Nutrients · 2021Review
- NGS Gene Panel Analysis Revealed Novel Mutations in Patients with Rare Congenital Diarrheal Disorders.Diagnostics (Basel, Switzerland) · 2021Article
- Congenital Tufting Enteropathy: Biology, Pathogenesis and Mechanisms.Journal of clinical medicine · 2020Review
- Tufting Enteropathy: A Review of Clinical and Histological Presentation, Etiology, Management, and Outcome.Gastroenterology research and practice · 2020Review
- Congenital chloride diarrhoea.BMJ case reports · 2019Article
- Congenital diarrhea in a newborn infant: A case report.World journal of clinical pediatrics · 2019Article
- Application of Whole Exome Sequencing in Congenital Secretory Diarrhea Diagnosis.Journal of pediatric gastroenterology and nutrition · 2019Article
- Congenital glucose-galactose malabsorption: A case report with a novelClinical case reports · 2019Article
- Recent advances in understanding and managing malabsorption: focus on microvillus inclusion disease.F1000Research · 2019Review
- Two cases of microvillous inclusion disease caused by novel mutations inClinical case reports · 2018Article
- Reversible deficits in apical transporter trafficking associated with deficiency in diacylglycerol acyltransferase.Traffic (Copenhagen, Denmark) · 2018Article
- Newcomers in paediatric GI pathology: childhood enteropathies including very early onset monogenic IBD.Virchows Archiv : an international journal of pathology · 2018Review
- Inflammatory Bowel Disease in Primary Immunodeficiencies.Current allergy and asthma reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital diarrheal disorders (CDDs) are a group of inherited enteropathies with a typical onset early in the life. Infants with these disorders have frequently chronic diarrhea of sufficient severity to require parenteral nutrition. For most CDDs the disease-gene is known and molecular analysis may contribute to an unequivocal diagnosis. We review CDDs on the basis of the genetic defect, focusing on the significant contribution of molecular analysis in the complex, multistep diagnostic work-up.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.