ArticleInternational journal of molecular sciences2012
Response surface methodology to optimize enzymatic preparation of Deapio-Platycodin D and Platycodin D from Radix Platycodi.
Article in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 29 citations in OpenAlex.
- Biotransformation and pharmacological activities of platycosides fromChinese herbal medicines · 2024Review
- Optimization of extraction condition for platycodin D fromFood science & nutrition · 2023Article
- Biotransformation of Platycosides, Saponins from Balloon Flower Root, into Bioactive Deglycosylated Platycosides.Antioxidants (Basel, Switzerland) · 2023Review
- Production of Deglucose-Apiose-Xylosylated Platycosides from Glycosylated Platycosides by Crude Enzyme fromJournal of microbiology and biotechnology · 2022Article
- Molecular Cloning and Functional Characterization of a β-Glucosidase Gene to Produce Platycodin D inFrontiers in plant science · 2022Article
- Article
- Improved Bioactivity of 3-O-β-D-Glucopyranosyl Platycosides in BiotransformedJournal of microbiology and biotechnology · 2021Article
- Biotransformation of Glycosylated Saponins in Balloon Flower Root Extract into 3-Journal of microbiology and biotechnology · 2020Article
- Conversion of Glycosylated Platycoside E to Deapiose-Xylosylated Platycodin D by Cytolase PCL5.International journal of molecular sciences · 2020Article
- The Pharmacological Effects and Health Benefits ofFoods (Basel, Switzerland) · 2020Review
- Enzymatic Biotransformation of Balloon Flower Root Saponins into Bioactive Platycodin D by Deglucosylation withInternational journal of molecular sciences · 2019Article
- Biocatalysis of Platycoside E and Platycodin D3 Using Fungal Extracellular β-Glucosidase Responsible for Rapid Platycodin D Production.International journal of molecular sciences · 2018Article
- Platycosides from the Roots of Platycodon grandiflorum and Their Health Benefits.Preventive nutrition and food science · 2014Review
- Highly efficient biotransformation of polydatin to resveratrol by snailase hydrolysis using response surface methodology optimization.Molecules (Basel, Switzerland) · 2013Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In the present work, we reported the enzymatic preparation of deapio-platycodin D (dPD) and platycodin D (PD) optimized by response surface methodology (RSM) from Radix Platycodi. During investigation of the hydrolysis of crude platycosides by various glycoside hydrolases, snailase showed a strong ability to transform deapio-platycoside E (dPE) and platycoside E (PE) into dPD and PD with 100% conversion. RSM was used to optimize the effects of the reaction temperature (35-45 °C), enzyme load (5-20%), and reaction time (4-24 h) on the conversion process. Validation of the RSM model was verified by the good agreement between the experimental and the predicted values of dPD and PD conversion yield. The optimum preparation conditions were as follows: temperature, 43 °C; enzyme load, 15%; reaction time, 22 h. The biotransformation pathways were dPE→dPD3→dPD and PE→PD3→PD, respectively. The determined method may be highly applicable for the enzymatic preparation of dPD and PD for medicinal purposes and also for commercial use.
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