ArticleThe Journal of comparative neurology2012
Forebrain GABAergic projections from the dorsal raphe nucleus identified by using GAD67-GFP knock-in mice.
Article in The Journal of comparative neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 62 citations in OpenAlex.
- Cellular and molecular coding of habit-driven behavior in the dorsal raphe nucleus.bioRxiv : the preprint server for biology · 2026Article
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- Exploring the effects of adolescent social isolation stress on the serotonin system and ethanol-motivated behaviors.Psychopharmacology · 2025Article
- Dorsal raphe to basolateral amygdala corticotropin-releasing factor circuit regulates cocaine-memory reconsolidation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Dorsal Raphe to Basolateral Amygdala Corticotropin-Releasing Factor Circuit Regulates Cocaine-Memory Reconsolidation.bioRxiv : the preprint server for biology · 2024Article
- Role of neuropeptide neuromedin U in the nucleus accumbens shell in cocaine self-administration in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Top-down projections of the prefrontal cortex to the ventral tegmental area, laterodorsal tegmental nucleus, and median raphe nucleus.Brain structure & function · 2022Article
- Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder.IBRO neuroscience reports · 2021Review
- Reciprocal Lateral Hypothalamic and Raphe GABAergic Projections Promote Wakefulness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Diversity and function of corticopetal and corticofugal GABAergic projection neurons.Nature reviews. Neuroscience · 2020Review
- Article
- Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice.The Journal of veterinary medical science · 2020Article
- Serotonergic Plasticity in the Dorsal Raphe Nucleus Characterizes Susceptibility and Resilience to Anhedonia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Impaired Fear Extinction Recall in Serotonin Transporter Knockout Rats Is Transiently Alleviated during Adolescence.Brain sciences · 2019Article
- Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons.Frontiers in neuroscience · 2019Article
- Chronic Fluoxetine Induces Activity Changes in Recovery From Poststroke Anxiety, Depression, and Cognitive Impairment.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Article
- Serotonin neuron development: shaping molecular and structural identities.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Neurochemical differences between target-specific populations of rat dorsal raphe projection neurons.Brain research · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The dorsal raphe nucleus (DR) contains serotonergic (5-HT) neurons that project widely throughout the forebrain. These forebrain regions also receive innervation from non-5-HT neurons in the DR. One of the main groups of non-5-HT neurons in the DR is γ-aminobutyric acid (GABA)ergic, but their projections are poorly understood due to the difficulty of labeling these neurons immunohistochemically. To identify GABAergic projection neurons within the DR in the current study, we used a knock-in mouse line in which expression of green fluorescent protein (GFP) is controlled by the glutamic acid decarboxylase (GAD)67 promotor. Projections of GAD67-GFP neurons to the prefrontal cortex (PFC), nucleus accumbens (NAC), and lateral hypothalamus (LH) were evaluated by using retrograde tract tracing. The location of GAD67-GFP neurons projecting to each of these areas was mapped by rostrocaudal and dorsoventral location within the DR. Overall, 16% of DR neurons projecting to either the PFC or NAC were identified as GAD67-GFP neurons. GAD67-GFP neurons projecting to the PFC were most commonly found ventrally, in the rostral two-thirds of the DR. NAC-projecting GAD67-GFP neurons had an overlapping distribution that extended dorsally. GAD67-GFP neurons made a larger contribution to the projection of the DR to the LH, accounting for 36% of retrogradely labeled neurons, and were widespread throughout the DR. The current data indicate that DR GABAergic neurons not only may have the capacity to influence local network activity, but also make a notable contribution to DR output to multiple forebrain targets. J. Comp. Neurol. 520:4157-4167, 2012. © 2012 Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.