ArticleWiley interdisciplinary reviews. Systems biology and medicine
Sex and the circuitry: progress toward a systems-level understanding of vertebrate sex determination.
Article in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 78 citations in OpenAlex.
- Chromatin-Based Control of Mammalian Sex Determination: Integrating Epigenetic and Metabolic Mechanisms.Advances in experimental medicine and biology · 2026Review
- The basic helix-loop-helix transcription factor TCF4 recruits the Mediator Complex to activate gonadal genes and drive ovarian development.bioRxiv : the preprint server for biology · 2025Article
- Article
- Heat inducible nuclear translocation of Kdm6bb drives temperature dependent sex reversal in Nile tilapia.PLoS genetics · 2025Article
- Epigenetic control ofHeliyon · 2024Article
- Identification and characterization of the Dmrt1B gene in the oriental river prawn, Macrobrachium nipponense.Development genes and evolution · 2024Article
- Temperature-Induced Sex Differentiation in River Prawn (International journal of molecular sciences · 2024Article
- Cytogenomic Investigation of Syndromic Brazilian Patients with Differences of Sexual Development.Diagnostics (Basel, Switzerland) · 2023Article
- Effect of high temperatures on sex ratio and differential expression analysis (RNA-seq) of sex-determining genes inEnvironmental epigenetics · 2023Article
- Feminization of channel catfish with 17β-oestradiol involves methylation and expression of a specific set of genes independent of the sex determination region.Epigenetics · 2022Article
- The homeobox gene TGIF1 is required for chicken ovarian cortical development and generation of the juxtacortical medulla.Development (Cambridge, England) · 2021Article
- Epigenetic Regulation and Environmental Sex Determination in Cichlid Fishes.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2021Review
- The Model of the Conserved Epigenetic Regulation of Sex.Frontiers in genetics · 2019Article
- Logical modelling uncovers developmental constraints for primary sex determination of chicken gonads.Journal of the Royal Society, Interface · 2018Article
- Gonad Transcriptome Analysis of the Pacific Oyster Crassostrea gigas Identifies Potential Genes Regulating the Sex Determination and Differentiation Process.Marine biotechnology (New York, N.Y.) · 2018Article
- Vertebrate sex determination: evolutionary plasticity of a fundamental switch.Nature reviews. Genetics · 2017Review
- In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures.Nucleic acids research · 2017Article
- Article
- Article
- Polygenic sex determination in the cichlid fish Astatotilapia burtoni.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In vertebrates, the gonad arises as a bipotential primordium that can differentiate as a testis or ovary. Cells are initially primed to adopt either fate by balanced antagonistic signaling pathways and transcription networks. Sexual fate is determined by activating the testis or ovarian pathway and repressing the alternative pathway. A complex, dynamic transcription network underlies this process, as approximately half the genome is being transcribed during this period, and many genes are expressed in a sexually dimorphic manner. This network is highly plastic; however, multiple lines of evidence suggest that many elements of the pathway converge on the stabilization or disruption of Sox9 expression. The single gene mutational approach has led to the identification of ∼30 additional genes involved in vertebrate sex determination. However, >50% of human disorders of sexual development (DSDs) are not explained by any of these genes, suggesting many critical elements of the system await discovery. Emerging technologies and genetic resources enable the investigation of the sex determination network on a global scale in the context of a variable genetic background or environmental influences. Using these new tools we can investigate how cells establish a bipotential state that is poised to adopt either sexual fate, and how they integrate multiple signaling and transcriptional inputs to drive a cell fate decision. Elucidating the genetic architecture underlying sex determination in model systems can lead to the identification of conserved modules correlated with phenotypic outcomes, and critical pressure points in the network that predict genes involved in DSDs in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.