Evidence map›Paper›PMID 22605573›Full record

Trial reportAnnals of neurology2012

Dietary fat types and 4-year cognitive change in community-dwelling older women.

Olivia I Okereke, Bernard A Rosner, Dae H Kim, Jae H Kang, Nancy R Cook, JoAnn E Manson, Julie E Buring, Walter C Willett, Francine Grodstein

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Mediterranean diet and cognitive function in older age.Epidemiology (Cambridge, Mass.) · 2013
    Trial
  6. Diabetes-Associated Cognitive Impairment: Pathophysiology and Emerging Therapies.Annals of clinical and translational neurology · 2026
    Review
  7. Article
  8. Article
  9. Article
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  12. Article
  13. Article
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  15. Article
  16. Article
  17. Review
  18. Observational
  19. Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Olivia I OkerekeChanning Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. olivia.okereke@channing.harvard.edu
Bernard A Rosner
Dae H Kim
Jae H Kang
Nancy R Cook
JoAnn E Manson
Julie E Buring
Walter C Willett
Francine Grodstein

Funding

Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
Women's Health Study: Continued Follow-UpR01HL080467 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E. · 2005 to 2010
$4.5M
TRIALS OF PREVENTION OF COGNITIVE DECLINE IN WOMEN AND MR01AG015933 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GRODSTEIN, FRANCINE · 1998 to 2007
$2.4M
TRIAL OF VITAMIN E, BETA-CAROTENE &ASPRIN IN WOMENR01HL043851 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1991 to 2000
$1.6M
Dietary Fat Composition, Plasma Lipids, and Cognitive DeclineK08AG029813 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI OKEREKE, OLIVIA IFEOMA · 2008 to 2011
$531k
NCI NIH HHS CA047988NCI NIH HHS R01 CA047988NHLBI NIH HHS HL080467NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL080467NIA NIH HHS AG015933NIA NIH HHS K08 AG029813NIA NIH HHS R01 AG015933
6 · The paper itself

Abstract

objectiveA study was undertaken to relate dietary fat types to cognitive change in healthy community-based elders.

methodsAmong 6,183 older participants in the Women's Health Study, we related intake of major fatty acids (saturated [SFA], monounsaturated [MUFA], total polyunsaturated [PUFA], trans-unsaturated) to late-life cognitive trajectory. Serial cognitive testing, conducted over 4 years, began 5 years after dietary assessment. Primary outcomes were global cognition (averaging tests of general cognition, verbal memory, and semantic fluency) and verbal memory (averaging tests of recall). We used analyses of response profiles and logistic regression to estimate multivariate-adjusted differences in cognitive trajectory and risk of worst cognitive change (worst 10%) by fat intake.

resultsHigher SFA intake was associated with worse global cognitive (p for linear trend = 0.008) and verbal memory (p for linear trend = 0.01) trajectories. There was a higher risk of worst cognitive change, comparing highest versus lowest SFA quintiles; the multivariate-adjusted odds ratio (OR) with 95% confidence interval (CI) was 1.64 (1.04-2.58) for global cognition and 1.65 (1.04-2.61) for verbal memory. By contrast, higher MUFA intake was related to better global cognitive (p for linear trend < 0.001) and verbal memory (p for linear trend = 0.009) trajectories, and lower OR (95% CI) of worst cognitive change in global cognition (0.52 [0.31-0.88]) and verbal memory (0.56 [0.34-0.94]). Total fat, PUFA, and trans-fat intakes were not associated with cognitive trajectory.

interpretationHigher SFA intake was associated with worse global cognitive and verbal memory trajectories, whereas higher MUFA intake was related to better trajectories. Thus, different consumption levels of the major specific fat types, rather than total fat intake itself, appeared to influence cognitive aging.

Indexed as

Dietary FatsAgedAged, 80 and overAgingCognitionCognition DisordersDouble-Blind MethodFemaleHealth SurveysHumansLongitudinal StudiesMemoryNeuropsychological TestsWomenDietary Fats

Identifiers

PMID22605573
PMCPMC3405188

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.