ArticleThe European respiratory journal2013
Bronchoalveolar lavage neuregulin-1 is elevated in acute lung injury and correlates with inflammation.
Article in The European respiratory journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Protective Gene Signatures in the Transition from SIRS to Sepsis: Insights from Integrative Transcriptomics and Validation Across Clinical Cohorts.Infection and drug resistance · 2026Article
- Overexpression of IL-8 augments the susceptibility to a hyperinflammatory phenotype in pediatric acute respiratory distress syndrome and correlates with adverse outcomes: a retrospective two-center study conducted in northwest China.Frontiers in pediatrics · 2026Article
- Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.Genome medicine · 2021Article
- Neuregulin, an Effector on Mitochondria Metabolism That Preserves Insulin Sensitivity.Frontiers in physiology · 2020Review
- Interleukin-6 is required for Neuregulin-1 induced HER2 signaling in lung epithelium.Biochemical and biophysical research communications · 2019Article
- HER2 Signaling Implicated in Regulating Alveolar Epithelial Permeability with Cyclic Stretch.International journal of molecular sciences · 2019Article
- Circulating markers of endothelial and alveolar epithelial dysfunction are associated with mortality in pediatric acute respiratory distress syndrome.Intensive care medicine · 2016Observational
- Cigarette Smoke Induces Human Epidermal Receptor 2-Dependent Changes in Epithelial Permeability.American journal of respiratory cell and molecular biology · 2016Article
- Pulmonary epithelial barrier function: some new players and mechanisms.American journal of physiology. Lung cellular and molecular physiology · 2015Review
- Neuregulin1-β decreases IL-1β-induced neutrophil adhesion to human brain microvascular endothelial cells.Translational stroke research · 2015Article
- HER2 activation results in β-catenin-dependent changes in pulmonary epithelial permeability.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Human epidermal growth factor receptor signaling in acute lung injury.American journal of respiratory cell and molecular biology · 2012Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Shedding of neuregulin (NRG)-1 from the pulmonary epithelium leads to activation of the epithelial human epidermal growth factor receptor (HER)2 receptor, increased pulmonary epithelial permeability and acute lung injury (ALI). We sought to determine whether NRG-1 was detectable and elevated in bronchoalveolar lavage (BAL) and plasma from patients with ALI compared with controls and to determine whether a correlation exists between NRG-1 and inflammation and outcome in ALI. Matched BAL and plasma samples were obtained from 23 ALI patients requiring intubation and mechanical ventilation. Control patients (n=5) included healthy volunteers. NRG-1 and indices of inflammation were measured in BAL and plasma via ELISA. The mean±sd BAL NRG-1 concentration in ALI patients was 187.0±21.35 pg·mL(-1) compared with 85.50±9.2 pg·mL(-1) in controls (p=0.001). Increased BAL NRG-1 was associated with markers of inflammation, and inversely correlated with ventilator-free days (VFDs; r= -0.51, p=0.015). Plasma NRG-1 was elevated in ALI patients compared with controls (611.7±354.2 versus 25.17±19.33 pg·mL(-1), p<0.001) and inversely correlated with VFDs (r= -0.51, p=0.04). These results confirm shedding of NRG-1 in ALI and suggest that the NRG-1-HER2 pathway is active in patients with ALI.
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