ReviewNature chemical biology2012
Engineering synthetic recursive pathways to generate non-natural small molecules.
Review in Nature chemical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Review
- System metabolic engineering ofFrontiers in bioengineering and biotechnology · 2023Article
- An orthogonal metabolic framework for one-carbon utilization.Nature metabolism · 2021Article
- Genome-scale target identification in Escherichia coli for high-titer production of free fatty acids.Nature communications · 2021Article
- The 3-ketoacyl-CoA thiolase: an engineered enzyme for carbon chain elongation of chemical compounds.Applied microbiology and biotechnology · 2020Review
- Emergence of Function and Selection from Recursively Programmed Polymerisation Reactions in Mineral Environments.Angewandte Chemie (International ed. in English) · 2019Article
- In vivo biosensors: mechanisms, development, and applications.Journal of industrial microbiology & biotechnology · 2018Article
- Construction and evolution of anProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Engineering of Escherichia coli for direct and modulated biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer using unrelated carbon sources.Scientific reports · 2016Article
- A microbial factory for diverse chemicals.Nature biotechnology · 2016Article
- Systems Metabolic Engineering of Escherichia coli.EcoSal Plus · 2016Review
- Engineering Escherichia coli for Microbial Production of Butanone.Applied and environmental microbiology · 2016Article
- Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway.Nature communications · 2015Article
- Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum.Nature communications · 2015Article
- Biosynthesis and genomic analysis of medium-chain hydrocarbon production by the endophytic fungal isolate Nigrograna mackinnonii E5202H.Applied microbiology and biotechnology · 2015Article
- When plants produce not enough or at all: metabolic engineering of flavonoids in microbial hosts.Frontiers in plant science · 2015Review
- Improving fatty acids production by engineering dynamic pathway regulation and metabolic control.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Cloning, expression, purification, crystallization and X-ray crystallographic analysis of (S)-3-hydroxybutyryl-CoA dehydrogenase from Clostridium butyricum.Acta crystallographica. Section F, Structural biology communications · 2014Article
- Creating biological nanomaterials using synthetic biology.Science and technology of advanced materials · 2014Review
- Engineering complex biological systems in bacteria through recombinase-assisted genome engineering.Nature protocols · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recursive pathways are broadly defined as those that catalyze a series of reactions such that the key, bond-forming functional group of the substrate is always regenerated in each cycle, allowing for a new cycle of reactions to begin. Recursive carbon-chain elongation pathways in nature produce fatty acids, polyketides, isoprenoids and α-keto acids (αKAs), which all use modular or iterative approaches for chain elongation. Recently, an artificial pathway for αKA elongation has been built that uses an engineered isopropylmalate synthase to recursively condense acetyl-CoA with αKAs. This synthetic approach expands the possibilities for recursive pathways beyond the modular or iterative synthesis of natural products and serves as a case study for understanding the challenges of building recursive pathways from nonrecursive enzymes. There exists the potential to design synthetic recursive pathways far beyond what nature has evolved.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.