ArticleDiabetes care2012
Association of adiposity trajectories with insulin sensitivity and glycemic deterioration: a longitudinal study of rural Chinese twin adults.
Article in Diabetes care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Age of obesity onset, cumulative obesity exposure over early adulthood and risk of type 2 diabetes.Diabetologia · 2020Article
- A statistical model to describe longitudinal and correlated metabolic risk factors: the Whitehall II prospective study.Journal of public health (Oxford, England) · 2016Article
- Waist circumference, trunk and visceral fat cutoff values for detecting hyperinsulinemia and insulin resistance in children: the Healthy Growth Study.European journal of nutrition · 2016Article
- Trajectory of body mass index before the development of type 2 diabetes in Japanese men: Toranomon Hospital Health Management Center Study 15.Journal of diabetes investigation · 2015Article
- Longitudinal association of anthropometric measures of adiposity with cardiometabolic risk factors in postmenopausal women.Annals of epidemiology · 2014Article
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Authors and funding
13 authors.
Funding
Abstract
objectiveTo evaluate associations between adiposity trajectories over time and insulin sensitivity and glucose deterioration in a Chinese twin cohort. RESEARCH DESIGN AND
methodsThis study focused on 341 males and 292 females aged 20-50 years at baseline who had physical clinical examinations and oral glucose tolerance test at two time points with an average of 6 years apart. BMI, waist circumference, percent body fat (PBF), and percent trunk fat (PTF) trajectories were classified into five track groups based on age- and sex-specific tertiles at each visit. We calculated the odds of the insulin sensitivity index((0,120)) [ISI((0,120))] or glycemic deterioration at follow-up among five defined trajectories (tertile(baseline) → tertile(follow-up)) using generalized estimate equation models. Additionally, we applied structural equation models to examine genetic and environmental influences on adiposity, adiposity change over time (ACO), ISI((0,120)), and the interrelationships among them.
resultsParticipants with stable adiposity (BMI, waist circumference, PBF, and PTF) in the highest tertile or shifting to the highest tertile tended to have the lowest ISI((0,120)) at follow-up or experience glycemic deterioration. Genetic factors exerted the major influence on adiposity, but environmental factors unique to each twin contributed more strongly to ISI and ACO. Correlations between adiposity/ACO and insulin sensitivity were mainly due to environmental influences.
conclusionsWhen adiposity stays or becomes high, insulin sensitivity falls and risk of glycemic deterioration rises. Additionally, we found that genetic factors exerted the major influence on adiposity, while environmental factors played the principal role for ACO and insulin sensitivity.
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