Trial reportDiseases of the colon and rectum2012
Chromosomal copy number alterations are associated with persistent lymph node metastasis after chemoradiation in locally advanced rectal cancer.
Trial report in Diseases of the colon and rectum, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Copy number alterations and allelic ratio in relation to recurrence of rectal cancer.BMC genomics · 2015Pooled it
- [Lymph node metastases in ypT1/2 rectal cancer after neoadjuvant chemoradiotherapy : The Achilles heel of organ-preserving operative procedures?].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2016Trial
- Integrative genomic analysis identifies clinically relevant prognostic markers for colorectal cancer patients with liver metastasis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Copy Number Alterations as Novel Biomarkers and Therapeutic Targets in Colorectal Cancer.Cancers · 2022Review
- Application of machine learning techniques in real-world research to predict the risk of liver metastasis in rectal cancer.Frontiers in oncology · 2022Article
- A nomogram to predict the prognosis of patients with unresected rectal adenocarcinoma undergoing chemoradiotherapy: a population-based study.Journal of Cancer · 2021Article
- Local excision following chemoradiotherapy in T2-T3 rectal cancer: current status and critical appraisal.Updates in surgery · 2020Review
- Molecular Biology: Are We Getting Any Closer to Providing Clinically Useful Information?Clinics in colon and rectal surgery · 2017Review
- Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer.Experimental and therapeutic medicine · 2017Article
- Transanal endoscopic microsurgery for rectal cancer: T1 and beyond? An evidence-based review.Surgical endoscopy · 2016Review
- Integrated genomic profiling identifies microRNA-92a regulation of IQGAP2 in locally advanced rectal cancer.Genes, chromosomes & cancer · 2016Article
- Nomogram to predict ypN status after chemoradiation in patients with locally advanced rectal cancer.British journal of cancer · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLymph node metastasis is an important indicator of oncologic outcome for patients with rectal cancer. Identifying predictive biomarkers of lymph node metastasis could therefore be clinically useful.
objectiveThe aim of this study was to assess whether chromosomal copy number alterations can assist in predicting persistent lymph node metastasis in patients with locally advanced rectal cancer treated with preoperative chemoradiation therapy.
designThis is a nonrandomized, prospective phase II study.
settingThis study took place in a multi-institutional setting. PATIENTS: Ninety-five patients with stage II (cT3-4, cN0) or stage III (any cT, cN1-2) rectal cancer were included.
interventionPatients were treated with preoperative chemoradiation therapy followed by total mesorectal excision. Pretreatment biopsy tumor DNA and surgical margin control DNA were extracted and analyzed by oligonucleotide array-based comparative genomic hybridization. Chromosomal copy number alterations were correlated with persistent lymph node metastasis. Finally, a model for predicting persistent lymph node metastasis was built.
main outcome measuresThe primary outcomes assessed were whether chromosomal copy number alterations are associated with persistent lymph node metastasis in patients with rectal cancer and the accuracy of oligonucleotide array-based comparative genomic hybridization for predicting lymph node metastasis.
resultsTwenty-five of 95 (26%) patients had lymph node metastasis after chemoradiation. Losses of 28 chromosomal regions, most notably in chromosome 4, were significantly associated with lymph node metastasis. Our predictive model contained 65 probes and predicted persistent lymph node metastasis with 68% sensitivity, 93% specificity, and positive and negative predictive values of 77% and 89%. The use of this model accurately predicted lymph node status (positive or negative) after chemoradiation therapy in 82 of 95 patients (86%). LIMITATIONS: The patient cohort was not completely homogeneous, which may have influenced their clinical outcome. In addition, although we performed rigorous, statistically sound internal validation, external validation will be important to further corroborate our findings.
conclusionsCopy number alterations can help identify patients with rectal cancer who are at risk of lymph node metastasis after chemoradiation.
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