ReviewNature reviews. Neuroscience2012
Insights into CNS ageing from animal models of senescence.
Review in Nature reviews. Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 97 citations in OpenAlex.
- Age-related degradation of behavioral and network features ofFrontiers in aging neuroscience · 2026Article
- Age-related degradation of behavioral and network features ofbioRxiv : the preprint server for biology · 2025Article
- Functional mapping of the molluscan brain guided by synchrotron X-ray tomography.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna.Immunity & ageing : I & A · 2024Article
- Absent in melanoma 2 mediates aging-related cognitive dysfunction by acting on complement-dependent microglial phagocytosis.Aging cell · 2023Article
- Age-related Loss of miR-124 Causes Cognitive DeficitsAging and disease · 2022Article
- Age-associated gut microbiota impair hippocampus-dependent memory in a vagus-dependent manner.JCI insight · 2022Article
- Effects of Transcranial Direct Current Stimulation on Memory of Elderly People with Mild Cognitive Impairment or Alzheimer's Disease: A Systematic Review.Journal of central nervous system disease · 2022Review
- Contribution of TMS and TMS-EEG to the Understanding of Mechanisms Underlying Physiological Brain Aging.Brain sciences · 2021Review
- A Multivariate Assessment of Age-Related Cognitive Impairment inFrontiers in integrative neuroscience · 2021Article
- Sleep and ageing: from human studies to rodent models.Current opinion in physiology · 2020Article
- Stem Cells of the Aging Brain.Frontiers in aging neuroscience · 2020Review
- Review
- Senescent neurophysiology: CaNeurobiology of learning and memory · 2019Review
- Astrocytes and the TGF-β1 Pathway in the Healthy and Diseased Brain: a Double-Edged Sword.Molecular neurobiology · 2019Review
- Changes in murine anorectum signaling across the life course.Neurogastroenterology and motility · 2018Article
- Effects of Aging on Cortical Neural Dynamics and Local Sleep Homeostasis in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Vitamin transporters in mice brain with aging.Journal of anatomy · 2018Article
- Neuroprotective Natural Molecules, From Food to Brain.Frontiers in neuroscience · 2018Review
- Brain Networks Reorganization During Maturation and Healthy Aging-Emphases for Resilience.Frontiers in psychiatry · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In recent years, novel model systems have made significant contributions to our understanding of the processes that control the ageing of whole organisms. However, there are limited data to show that the mechanisms that gerontologists have identified as having a role in organismal ageing contribute significantly to the ageing of the central nervous system. Two recent discoveries illustrate this particularly well. The first is the consistent failure of researchers to demonstrate a simple relationship between organismal ageing and oxidative stress--a mechanism often assumed to have a primary role in brain ageing. The second is the demonstration that senescent cells play a causal part in organismal ageing but remain essentially unstudied in a CNS context. We argue that the animal models now available (including rodents, flies, molluscs and worms), if properly applied, will allow a paradigm shift in our current understanding of the normal processes of brain ageing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.