ArticlePsychiatry research2012
Prefrontal cortical response to emotional faces in individuals with major depressive disorder in remission.
Article in Psychiatry research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Meta-analysis of neural correlates of working memory, reward, and emotion processing in major depressive disorder using ALE.Psychological medicine · 2026Pooled it
- Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder.Journal of affective disorders · 2024Article
- A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults.Journal of affective disorders · 2022Article
- Neuroticism in temporal lobe epilepsy is associated with altered limbic-frontal lobe resting-state functional connectivity.Epilepsy & behavior : E&B · 2020Article
- Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans.Frontiers in human neuroscience · 2020Article
- Article
- Gray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disorders.Journal of affective disorders · 2019Article
- Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder.Frontiers in psychiatry · 2019Article
- Shared facial emotion processing functional network findings in medication-naïve major depressive disorder and healthy individuals: detection by sICA.BMC psychiatry · 2018Article
- Considering sex differences clarifies the effects of depression on facial emotion processing during fMRI.Journal of affective disorders · 2018Article
- [Research on the effects of the continuous theta-burst transcranial magnetic stimuli on brain network in emotional processing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2017Article
- FMRI Study of Neural Responses to Implicit Infant Emotion in Anorexia Nervosa.Frontiers in psychology · 2017Article
- Positive Affectivity is Dampened in Youths with Histories of Major Depression and Their Never-Depressed Adolescent Siblings.Clinical psychological science : a journal of the Association for Psychological Science · 2016Article
- Amygdala and dorsomedial hyperactivity to emotional faces in youth with remitted Major Depression.Social cognitive and affective neuroscience · 2016Article
- Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder.Psychological medicine · 2016Article
- Just Swap Out of Negative Vibes? Rumination and Inhibition Deficits in Major Depressive Disorder: Data from Event-Related Potentials Studies.Frontiers in psychology · 2016Review
- A functional MRI study of altered spontaneous brain activity pattern in patients with congenital comitant strabismus using amplitude of low-frequency fluctuation.Neuropsychiatric disease and treatment · 2016Article
- Article
- Affective personality predictors of disrupted reward learning and pursuit in major depressive disorder.Psychiatry research · 2015Article
- Baseline brain perfusion and brain structure in patients with major depression: a multimodal magnetic resonance imaging study.Journal of psychiatry & neuroscience : JPN · 2015Article
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
Abstract
Abnormalities in the response of the orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC) to negative emotional stimuli have been reported in acutely depressed patients. However, there is a paucity of studies conducted in unmedicated individuals with major depressive disorder in remission (rMDD) to assess whether these are trait abnormalities. To address this issue, 19 medication-free rMDD individuals and 20 healthy comparison (HC) participants were scanned using functional magnetic resonance imaging while performing an implicit emotion processing task in which they labeled the gender of faces depicting negative (fearful), positive (happy) and neutral facial expressions. The rMDD and HC groups were compared using a region-of-interest approach for two contrasts: fear vs. neutral and happy vs. neutral. Relative to HC, rMDD showed reduced activation in left OFC and DLPFC to fearful (vs. neutral) faces. Right DLPFC activation to fearful (vs. neutral) faces in the rMDD group showed a significant positive correlation with duration of euthymia. The findings support deficits in left OFC and DLPFC responses to negative emotional stimuli during euthymic periods of MDD, which may reflect trait markers of the illness or a 'scar' due to previous depression. Recovery may also be associated with compensatory increases in right DLPFC functioning.
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