ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2012
Respiratory viral pathogens associated with lower respiratory tract disease among young children in the highlands of Papua New Guinea.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
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- Post-pandemic influenza A/H1N1pdm09 is associated with more severe outcomes than A/H3N2 and other respiratory viruses in adult hospitalisations.Epidemiology and infection · 2019Article
- Nasal Cytokine Profiles of Patients Hospitalised with Respiratory Wheeze Associated with Rhinovirus C.Viruses · 2019Article
- Respiratory Illness in a Piggery Associated with the First Identified Outbreak of Swine Influenza in Australia: Assessing the Risk to Human Health and Zoonotic Potential.Tropical medicine and infectious disease · 2019Article
- Rhinovirus C is associated with wheezing and rhinovirus A is associated with pneumonia in hospitalized children in Morocco.Journal of medical virology · 2017Article
- Clinical characteristics of eosinophilic asthma exacerbations.Respirology (Carlton, Vic.) · 2017Article
- Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adults.Respiratory medicine · 2017Observational
- Child pneumonia - focus on the Western Pacific Region.Paediatric respiratory reviews · 2017Review
- Childhood pneumonia and meningitis in the Eastern Highlands Province, Papua New Guinea in the era of conjugate vaccines: study methods and challenges.Pneumonia (Nathan Qld.) · 2017Article
- Rhinovirus species and clinical features in children hospitalised with pneumonia from Mozambique.Tropical medicine & international health : TM & IH · 2016Article
- Update on Human Rhinovirus and Coronavirus Infections.Seminars in respiratory and critical care medicine · 2016Review
- Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2016Article
- Severe Acute Respiratory Illness Deaths in Sub-Saharan Africa and the Role of Influenza: A Case Series From 8 Countries.The Journal of infectious diseases · 2015Article
- Viruses associated with influenza-like-illnesses in Papua New Guinea, 2010.Journal of medical virology · 2014Article
- Influenza and respiratory syncytial virus are the major respiratory viruses detected from prospective testing of pediatric and adult coronial autopsies.Influenza and other respiratory viruses · 2013Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAcute lower respiratory tract infections (ALRI) commonly result in fatal outcomes in the young children of Papua New Guinea (PNG). However, comprehensive studies of the viral aetiology of ALRI have not been conducted in PNG for almost 30 years.
objectivesTo determine the viruses associated with ALRI among children living in the PNG highlands using sensitive molecular detection techniques. STUDY
designPernasal swabs were collected routinely between 1 week and 18 months of age and also during episodes of ALRI, as part of a neonatal pneumococcal conjugate vaccine trial. A tandem multiplex real-time PCR assay was used to test for a comprehensive range of respiratory viruses in samples collected from 221 young children. Picornavirus typing was supported by DNA sequence analysis.
resultsRecognized pathogenic respiratory viruses were detected in 198/273 (73%) samples collected from children with no evidence of ALRI and 69/80 (86%) samples collected during ALRI episodes. Human rhinoviruses (HRV) species A, B and C were detected in 152 (56%) samples from non-ALRI children and 50 (63%) samples collected during ALRI episodes. Partial structural region sequences for two new species C rhinoviruses were added to the GenBank database. ALRI was associated with detection of adenovirus species B (p<0.01) or C (p<0.05), influenza A (p<0.0001) or respiratory syncytial virus (p<0.0001). Multiple viruses were detected more often during ALRI episodes (49%) than when children displayed no symptoms of ALRI (18%) (p<0.0001).
conclusionsThe burden of infection with respiratory viruses remains significant in young children living in the PNG highlands.
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Registered trials
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