ArticleJournal of the American Society of Nephrology : JASN2012
Renal denervation in moderate to severe CKD.
Article in Journal of the American Society of Nephrology : JASN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 134 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Open-label Study Investigating the Effect of Bilateral Renal Artery Sympathetic Denervation by Catheter-based Radiofrequency Ablation on Blood Pressure and Disease Progression in Autosomal Dominant Polycystic Kidney Disease
Effect of Renal Denervation on Blood Pressure in Patients With Chronic Kidney Disease and Uncontrolled Hypertension
Effect of Renal Denervation on Blood Pressure in Patients With Chronic Kidney Disease and Uncontrolled Hypertension
Who cites it
134 citing papers in PubMed, 7 syntheses or guidelines pooled it, 354 citations in OpenAlex.
- Pooled it
- The role of renal denervation for the treatment of hypertension in patients with chronic kidney disease: a position paper of the Italian Society of Nephrology.Journal of nephrology · 2025Guideline
- Effects of renal denervation on kidney function in patients with chronic kidney disease: a systematic review and meta-analysis.Journal of human hypertension · 2024Pooled it
- Effects of catheter-based renal denervation on renin-aldosterone system, catecholamines, and electrolytes: A systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2022Pooled it
- Systematic review of renal denervation for the management of cardiac arrhythmias.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Pooled it
- Renal sympathetic denervation for treatment of resistant hypertension: a systematic review.Journal of clinical hypertension (Greenwich, Conn.) · 2013Pooled it
- Renal artery denervation for treating resistant hypertension : definition of the disease, patient selection and description of the procedure.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2012Guideline
- Renal Safety of Distal Renal Denervation on Kidney Function in Diabetic Patients with Resistant Hypertension.Medicina (Kaunas, Lithuania) · 2026Trial
- Pleiotropic effects of renal denervation beyond blood pressure reduction.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Renal denervation triage tool: a practical approach to the management of resistant hypertension.AsiaIntervention · 2026Review
- Clinical research progress of renal denervation for heart failure treatment: current evidence, controversies, and future directions.Frontiers in cardiovascular medicine · 2026Review
- Renal Denervation in Patients With Moderate to Severe Chronic Kidney Disease.Hypertension (Dallas, Tex. : 1979) · 2025Observational
- Increased plasma levels of erythropoietin after renal denervation in patients with resistant hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Future perspective on chronic kidney disease management.Journal of anesthesia and translational medicine · 2025Review
- Safety and Efficacy of Renal Denervation for the Treatment of Resistant Hypertension in Patients with Chronic Kidney Disease: A Narrative Review of the Literature.Biomedicines · 2025Review
- Renal denervation in dialysis patients: long-term outcomes in a real-world setting.Clinical kidney journal · 2025Article
- Renal denervation is effective in reducing blood pressure in patients with CKD.Clinical kidney journal · 2025Review
- Renal-Cardiac Crosstalk in the Pathogenesis and Progression of Heart Failure.Circulation research · 2025Review
- Renal nerves in physiology, pathophysiology and interoception.Nature reviews. Nephrology · 2025Review
- Effects of renal denervation on the kidney: albuminuria, proteinuria, and renal function.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
74 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sympathetic activation contributes to the progression of CKD and is associated with adverse cardiovascular outcomes. Ablation of renal sympathetic nerves reduces sympathetic nerve activity and BP in patients with resistant hypertension and preserved renal function, but whether this approach is safe and effective in patients with an estimated GFR (eGFR) < 45 ml/min per 1.73 m(2) is unknown. We performed bilateral renal denervation in 15 patients with resistant hypertension and stage 3-4 CKD (mean eGFR, 31 ml/min per 1.73 m(2)). We used CO(2) angiography in six patients to minimize exposure to contrast agents. Estimated GFR remained unchanged after the procedure, irrespective of the use of CO(2) angiography. Mean baseline BP ± SD was 174 ± 22/91 ± 16 mmHg despite the use of 5.6 ± 1.3 antihypertensive drugs. Mean changes in office systolic and diastolic BP at 1, 3, 6, and 12 months were -34/-14, -25/-11, -32/-15, and -33/-19 mmHg, respectively. Night-time ambulatory BP significantly decreased (P<0.05), restoring a more physiologic dipping pattern. In conclusion, this study suggests a favorable short-term safety profile and beneficial BP effects of catheter-based renal nerve ablation in patients with stage 3-4 CKD and resistant hypertension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.