Evidence map›Paper›PMID 22595300›Full record

ReviewCurrent opinion in virology2012

Interactions among capsid proteins orchestrate rotavirus particle functions.

Shane D Trask, Kristen M Ogden, John T Patton

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  4. Review
  5. Review
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  8. Journal of virology · 2019
    Article
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  15. Review
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  19. Rotavirus mRNAS are released by transcript-specific channels in the double-layered viral capsid.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Shane D TraskLaboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8026, USA.
Kristen M Ogden
John T Patton
National Institute of Allergy and Infectious Diseases · USNational Institutes of Health · US

Funding

Mechanism Of Rotavirus Genome Replication And PackagingZIAAI000754 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI PATTON, JOHN · 2009 to 2015
$3.4M
MODIFICATION OF THE ANTIGENICITY &VIRULENCE OF ROTAVIRUSES BY REVERSE GENETICSZ01AI000788 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI PATTON, JOHN · 1997 to 2008
$1.1M
Intramural NIH HHS Z01 AI000788Intramural NIH HHS ZIA AI000754
6 · The paper itself

Abstract

Rotaviruses are members of the Reoviridae family of non-enveloped viruses and important etiologic agents of acute gastroenteritis in infants and young children. In recent years, high-resolution structures of triple-layered rotavirus virions and the constituent proteins have provided valuable insights into functions. Of note, structural studies have revealed the position of the viral RNA-dependent RNA polymerase, VP1, within the inner capsid, which in turn provides clues about the location of the viral capping machinery and the route of viral transcript egress. Mechanisms by which the viral spike protein, VP4, mediates receptor binding and membrane penetration have also been aided by high-resolution structural studies. Future work may serve to fill the remaining gaps in understanding of rotavirus particle structure and function.

Indexed as

AnimalsCapsid ProteinsGastroenteritisHumansProtein BindingRotavirusRotavirus InfectionsCapsid Proteins

Identifiers

PMID22595300
PMCPMC3422376
OpenAlexW2057397861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.