Evidence map›Paper›PMID 22595165›Full record

ReviewJACC. Cardiovascular imaging2012

Cell tracking and the development of cell-based therapies: a view from the Cardiovascular Cell Therapy Research Network.

Martin Rodriguez-Porcel, Marvin W Kronenberg, Timothy D Henry, Jay H Traverse, Carl J Pepine, Stephen G Ellis, James T Willerson, Lemuel A Moyé, Robert D Simari

Abstract readReview
In one paragraph

Review in JACC. Cardiovascular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cardiac Cell Tracking with MRI Reporter Genes: Welcoming a New Field.Current cardiovascular imaging reports · 2014
    Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Martin Rodriguez-PorcelMayo Clinic, Rochester, Minnesota, USA.
Marvin W Kronenberg
Timothy D Henry
Jay H Traverse
Carl J Pepine
Stephen G Ellis
James T Willerson
Lemuel A Moyé
Robert D Simari

Funding

Data Coordinating Center For The Cardiovascular Cell Therapy Research NetworkUM1HL087318 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DAVIS, BARRY R · 2012 to 2018
$29.8M
Cardiovascular Cell Therapy Research Network - Data Coordinating CenterU01HL087318 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MOYE, LEMUEL A. · 2007 to 2011
$17.6M
UFRCC for Cardiovascular Cell Therapy Research NetworkUM1HL087366 · NHLBI · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J · 2012 to 2018
$4.7M
Ancillary Functional Studies for the CCTRNR01HL091005 · NHLBI · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J, SEGAL, MARK S. · 2008 to 2011
$1.5M
NHLBI NIH HHS R01 HL091005NHLBI NIH HHS U01 HL087318NHLBI NIH HHS UM1 HL087318NHLBI NIH HHS UM1 HL087366
6 · The paper itself

Abstract

Cell-based therapies are being developed for myocardial infarction (MI) and its consequences (e.g., heart failure) as well as refractory angina and critical limb ischemia. The promising results obtained in preclinical studies led to the translation of this strategy to clinical studies. To date, the initial results have been mixed: some studies showed benefit, whereas in others, no benefit was observed. There is a growing consensus among the scientific community that a better understanding of the fate of transplanted cells (e.g., cell homing and viability over time) will be critical for the long-term success of these strategies and that future studies should include an assessment of cell homing, engraftment, and fate as an integral part of the trial design. In this review, different imaging methods and technologies are discussed within the framework of the physiological answers that the imaging strategies can provide, with a special focus on the inherent regulatory issues.

Indexed as

Cell TrackingCell TransplantationAnimalsCell MovementCell SurvivalGenes, ReporterHumansMagnetic Resonance ImagingMyocardial InfarctionMyocardiumPositron-Emission TomographyRecovery of FunctionRegenerationTime FactorsTomography, Emission-Computed, Single-PhotonTreatment Outcome

Identifiers

PMID22595165
PMCPMC3632261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.