ArticleAmerican journal of public health2012
One community's effort to control genetic disease.
Article in American journal of public health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Spinal muscular atrophy within Amish and Mennonite populations: Ancestral haplotypes and natural history.PloS one · 2018Trial
- Trial-ready external controls for gene therapy: The MATCH cohort in maple syrup urine disease.Cell reports. Medicine · 2026Article
- Health Care Financing Practices Among U.S. Amish.Journal of community health · 2025Article
- Cross-sectional survey on genetic testing utilization and perceptions in Wisconsin Amish and Mennonite communities.Journal of community genetics · 2023Article
- Glycogen storage disease type 1a in the Ohio Amish.JIMD reports · 2022Article
- Under-referral of Plain community members for genetic services despite being qualified for genetic evaluation.Journal of genetic counseling · 2021Article
- Depression and Health Self-perception: Associations Within the Isolated Mennonite Population in South Brazil.Journal of immigrant and minority health · 2020Article
- Orthopaedic manifestations of glutaric acidemia Type 1.Journal of children's orthopaedics · 2020Article
- Maple syrup urine disease mutation spectrum in a cohort of 40 consanguineous patients and insilico analysis of novel mutations.Metabolic brain disease · 2019Article
- Trends in the characteristics of human functional genomic data on the gene expression omnibus, 2001-2017.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- Genetic pleiotropy between mood disorders, metabolic, and endocrine traits in a multigenerational pedigree.Translational psychiatry · 2018Article
- TNNT1 nemaline myopathy: natural history and therapeutic frontier.Human molecular genetics · 2018Article
- Genomic diagnostics within a medically underserved population: efficacy and implications.Genetics in medicine : official journal of the American College of Medical Genetics · 2018Article
- Assessing risk for Mendelian disorders in a Bronx population.Molecular genetics & genomic medicine · 2017Article
- Health Needs Assessment of Plain Populations in Lancaster County, Pennsylvania.Journal of community health · 2017Article
- Sharing the Load: Amish Healthcare Financing.Healthcare (Basel, Switzerland) · 2016Article
- Inborn Errors of Metabolism in the United Arab Emirates: Disorders Detected by Newborn Screening (2011-2014).JIMD reports · 2016Article
- A 26-hour system of highly sensitive whole genome sequencing for emergency management of genetic diseases.Genome medicine · 2015Article
- Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder.BMC genetics · 2015Article
- A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder.Human molecular genetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 1989, we established a small community health clinic to provide care for uninsured Amish and Mennonite children with genetic disorders. Over 20 years, we have used publicly available molecular data and sophisticated technologies to improve diagnostic efficiency, control laboratory costs, reduce hospitalizations, and prevent major neurological impairments within a rural underserved community. These actions allowed the clinic's 2010 operating budget of $1.5 million to save local communities an estimated $20 to $25 million in aggregate medical costs. This exposes an unsettling fact: our failure to improve the lot of most people stricken with genetic disease is no longer a matter of scientific ignorance or prohibitive costs but of choices we make about how to implement existing knowledge and resources.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.