ArticleTheoretical biology & medical modelling2012
A novel approach to the analysis of human growth.
Article in Theoretical biology & medical modelling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Z-score differences based on cross-sectional growth charts do not reflect the growth rate of very low birth weight infants.PloS one · 2019Observational
- Long-term response to recombinant human growth hormone treatment: a new predictive mathematical method.Journal of endocrinological investigation · 2018Article
- When carapace governs size: variation among age classes and individuals in a free-ranging ectotherm with delayed maturity.Oecologia · 2018Article
- A time-varying biased random walk approach to human growth.Scientific reports · 2017Article
- Dynamics of syndesmophyte growth in AS as measured by quantitative CT: heterogeneity within and among vertebral disc spaces.Rheumatology (Oxford, England) · 2015Article
- Growth impairment after TBI of leukemia survivors children: a model- based investigation.Theoretical biology & medical modelling · 2014Article
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Authors and funding
4 authors.
Funding
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Abstract
objectivesSeveral formulations have been proposed in order to model human growth from birth to maturity. They are usually based on "ad hoc" heuristic assumptions. In the present contribution we adopt, as an alternative, a completely general (interdisciplinary) approach, based on the formalism of the Phenomenological Universalities (PUN).
methodsThe main PUN class investigated to date, i.e. UN, can only account for the overall growth pattern. For a realistic description it is necessary to add to it one or more "spurts", as expected on biological grounds, due to the stimulation of growth and sex hormones.
resultsA new PUN class (UN + FM) is generated and shown to be able to provide excellent agreement with standard auxological datasets. The accuracy of the fitting and reliability of the model suggest applications both at the diagnostic and therapeutic level.
conclusionsThe developed formalism can be suitably related to the biological description of bone plate growth under selective hormonal stimulation on the bone epiphysis; i.e., the additional increase of stature is the "macroscopic" response to a well defined biological signal.
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