ArticleMalaria journal2012
Post-treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia.
Article in Malaria journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Systematic analysis of direct antiglobulin test results in post-artesunate delayed haemolysis.Malaria journal · 2021Pooled it
- Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial.PLoS medicine · 2016Trial
- A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal Cancer.EBioMedicine · 2015Trial
- Post-artesunate delayed hemolysis after treatment of malaria with intravenous artesunate: A case study.IDCases · 2022Article
- Safety and Effectiveness of Intravenous Artesunate for Treatment of Severe Malaria in the United States-April 2019 Through December 2020.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Case Report: Autoimmune Hemolysis Anemia After Dihydroartemisinin and Piperaquine for UncomplicatedFrontiers in medicine · 2021Article
- Positive direct antiglobulin test in post-artesunate delayed haemolysis: more than a coincidence?Malaria journal · 2019Article
- Different Life Cycle Stages ofFrontiers in immunology · 2019Article
- Artesunate-Induced Severe Autoimmune Hemolytic Anemia in Complicated Malaria.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2018Article
- Probucol dramatically enhances dihydroartemisinin effect in murine malaria.Malaria journal · 2016Article
- Severe falciparum malaria complicated by prolonged haemolysis and rhinomaxillary mucormycosis after parasite clearance: a case report.BMC infectious diseases · 2015Article
- Delayed Hemolysis After Parenteral Artesunate Therapy for Severe Malaria in Two Returning Canadian Travelers.The American journal of tropical medicine and hygiene · 2015Article
- Delayed-onset hemolytic anemia in patients with travel-associated severe malaria treated with artesunate, France, 2011-2013.Emerging infectious diseases · 2015Article
- Severe delayed hemolysis associated with regulated parenteral antimalarial drug.Emerging infectious diseases · 2015Article
- An imported case of severe falciparum malaria with prolonged hemolytic anemia clinically mimicking a coinfection with babesiosis.The Korean journal of parasitology · 2014Article
- Severe delayed autoimmune haemolytic anaemia following artesunate administration in severe malaria: a case report.Malaria journal · 2014Article
- Delayed anemia assessment in patients treated with oral artemisinin derivatives for uncomplicated malaria: a pooled analysis of clinical trials data from Mali.Malaria journal · 2014Article
- Postartesunate delayed hemolysis is a predictable event related to the lifesaving effect of artemisinins.Blood · 2014Article
- Haemolytic anaemia after oral artemether-lumefantrine treatment in a patient affected by severe imported falciparum malaria.Infection · 2013Article
- Current challenges in travelers' malaria.Current infectious disease reports · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parenteral artesunate has been shown to be a superior treatment option compared to parenteral quinine in adults and children with severe malaria. Little evidence, however, is available on long-term safety. Recently, cases of late-onset haemolysis after parenteral treatment with artesunate have been reported in European travellers with imported Plasmodium falciparum malaria. Therefore, an extended follow-up of adult patients treated for severe imported malaria was started in August 2011 at the University Medical Center Hamburg-Eppendorf. Until January 2012, three patients with hyperparasitaemia (range: 14-21%) were included for analysis. In all three patients, delayed haemolysis was detected in the second week after the first dose of intravenous artesunate. Reticulocyte production index remained inadequately low in the 7 - 14 days following the first dose of artesunate despite rapid parasite clearance. Post-treatment haemolysis after parenteral artesunate may be of clinical relevance in particular in imported severe malaria characterized by high parasite levels. Extended follow-up of at least 30 days including controls of haematological parameters after artesunate treatment seems to be indicated. Further investigations are needed to assess frequency and pathophysiological background of this complication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.