Trial reportAlcoholism, clinical and experimental research2012
Persistent dose-dependent changes in brain structure in young adults with low-to-moderate alcohol exposure in utero.
Trial report in Alcoholism, clinical and experimental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Prenatal alcohol exposure and associations with physical size, dysmorphology and neurodevelopment: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Persistent Alterations of Brain and Behavior in Children With Low Prenatal Alcohol Exposure.Biological psychiatry global open science · 2026Article
- Neurological Disorders Induced by Drug Use: Effects of Adolescent and Embryonic Drug Exposure on Behavioral Neurodevelopment.International journal of molecular sciences · 2024Review
- Prenatal exposure to alcohol and its impact on reward processing and substance use in adulthood.Translational psychiatry · 2024Article
- Prenatal alcohol exposure and attention-deficit/hyperactivity disorder independently predict greater substance use in young adulthood.Alcohol, clinical & experimental research · 2023Article
- Dose-Related Reduction in Hippocampal Neuronal Populations in Fetal Alcohol Exposed Vervet Monkeys.Brain sciences · 2022Article
- Alcohol and substance use in pregnancy during the COVID-19 pandemic.Drug and alcohol dependence · 2021Article
- Charting the trajectories of adopted children's emotional and behavioral problems: The impact of early adversity and postadoptive parental warmth.Development and psychopathology · 2021Article
- Association of Prenatal Alcohol Exposure With Psychological, Behavioral, and Neurodevelopmental Outcomes in Children From the Adolescent Brain Cognitive Development Study.The American journal of psychiatry · 2020Article
- Different brain profiles in children with prenatal alcohol exposure with or without early adverse exposures.Human brain mapping · 2020Article
- Association of Gray Matter and Personality Development With Increased Drunkenness Frequency During Adolescence.JAMA psychiatry · 2020Article
- Gender Differences in the Outcome of Offspring Prenatally Exposed to Drugs of Abuse.Frontiers in behavioral neuroscience · 2020Review
- Differentiating the Effects of Familial Risk for Alcohol Dependence and Prenatal Exposure to Alcohol on Offspring Brain Morphology.Alcoholism, clinical and experimental research · 2017Article
- Methamphetamine and cannabis abuse in adolescence: a quasi-experimental study on specific and long-term neurocognitive effects.BMJ open · 2015Article
- Self-regulation therapy increases frontal gray matter in children with fetal alcohol spectrum disorder: evaluation by voxel-based morphometry.Frontiers in human neuroscience · 2015Article
- Developmental consequences of fetal exposure to drugs: what we know and what we still must learn.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- A study of cortical morphology in children with fetal alcohol spectrum disorders.Human brain mapping · 2014Article
- A tensor-based morphometry analysis of regional differences in brain volume in relation to prenatal alcohol exposure.NeuroImage. Clinical · 2014Article
- Prenatal alcohol exposure and offspring cognition and school performance. A 'Mendelian randomization' natural experiment.International journal of epidemiology · 2013Article
- Commentary on Day and colleagues : the association between prenatal alcohol exposure and behavior at 22 years of age--adverse effects of risky patterns of drinking among low to moderate alcohol-using pregnant women.Alcoholism, clinical and experimental research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMany children with heavy exposure to alcohol in utero display characteristic alterations in brain size and structure. However, the long-term effects of low-to-moderate alcohol exposure on these outcomes are unknown.
methodsUsing voxel-based morphometry and region-of-interest analyses, we examined the influence of lower doses of alcohol on gray and white matter composition in a prospectively recruited, homogeneous, well-characterized cohort of alcohol-exposed (n = 11, age 19.5 ± 0.3 years) and control (n = 9, age 19.6 ± 0.5 years) young adults. A large proportion of the exposed individuals were born to mothers whose alcohol consumption during pregnancy was in the low-to-moderate range.
resultsThere were no differences in total brain volume or total gray or white matter volume between the exposed and control groups. However, gray matter volume was reduced in alcohol-exposed individuals in several areas previously reported to be affected by high levels of exposure, including the left cingulate gyrus, bilateral middle frontal gyri, right middle temporal gyrus, and right caudate nucleus. Notably, this gray matter loss was dose dependent, with higher exposure producing more substantial losses.
conclusionsThese results indicate that even at low doses, alcohol exposure during pregnancy impacts brain development and that these effects persist into young adulthood.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.