ArticleAdvances in urology2012
Focal therapy in the management of prostate cancer: an emerging approach for localized prostate cancer.
Article in Advances in urology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cryosurgery would be An Effective Option for Clinically Localized Prostate Cancer: A Meta-analysis and Systematic Review.Scientific reports · 2016Pooled it
- Outcomes of Active Treatment for Localised Prostate Cancer After Holmium Laser Enucleation of the Prostate: A Systematic Review and Meta-analysis.European urology open science · 2025Review
- Prostate Cancer Treatments and Their Effects on Male Fertility: Mechanisms and Mitigation Strategies.Journal of personalized medicine · 2025Review
- Transforming Prostate Cancer Care: Innovations in Diagnosis, Treatment, and Future Directions.International journal of molecular sciences · 2025Review
- Article
- Clinical application of the therapeutic ultrasound in urologic disease: Part II of therapeutic ultrasound in urology.Investigative and clinical urology · 2022Review
- Magnetic resonance image-guided focused ultrasound robotic system for transrectal prostate cancer therapy.The international journal of medical robotics + computer assisted surgery : MRCAS · 2021Article
- Percutaneous MR-guided prostate cancer cryoablation technical updates and literature review.BJR open · 2019Review
- Article
- TOOKAD® Soluble focal therapy: pooled analysis of three phase II studies assessing the minimally invasive ablation of localized prostate cancer.World journal of urology · 2015Article
- Low temperature plasma: a novel focal therapy for localized prostate cancer?BioMed research international · 2014Review
- Prediction of prostate cancer to urethra distance by a pretreatment nomogram: urethral thermoprotection implication in cryoablation.Prostate cancer and prostatic diseases · 2013Article
- Pubic bone osteomyelitis after salvage high-intensity focused ultrasound for prostate cancer.Current urology · 2013Article
- The role of targeted focal therapy in the management of low-risk prostate cancer: update on current challenges.Prostate cancer · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A widespread screening with prostate-specific antigen (PSA) has led increased diagnosis of localized prostate cancer along with a reduction in the proportion of advanced-stage disease at diagnosis. Over the past decade, interest in focal therapy as a less morbid option for the treatment of localized low-risk prostate cancer has recently been renewed due to downward stage migration. Focal therapy stands midway between active surveillance and radical treatments, combining minimal morbidity with cancer control. Several techniques of focal therapy have potential for isolated ablation of a tumor focus with sparing of uninvolved surround tissue demonstrating excellent short-term cancer control and a favorable patient's quality of life. However, to date, tissue ablation has mostly used for near-whole prostate gland ablation without taking advantage of accompanying the technological capabilities. The available ablative technologies include cryotherapy, high-intensity focused ultrasound (HIFU), and vascular-targeted photodynamic therapy (VTP). Despite the interest in focal therapy, this technology has not yet been a well-established procedure nor provided sufficient data, because of the lack of randomized trial comparing the efficacy and morbidity of the standard treatment options. In this paper we briefly summarize the recent data regarding focal therapy for prostate cancer and these new therapeutic modalities.
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Registered trials
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