ArticleMetabolomics : Official journal of the Metabolomic Society2012
Characterization of the natural variation in Arabidopsis thaliana metabolome by the analysis of metabolic distance.
Article in Metabolomics : Official journal of the Metabolomic Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Systematic mass-spectrometry-guided metabolic fingerprinting elucidates diversity of specialized metabolites across the Brassicaceae.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Natural variation in root exudate composition in the genetically structured Arabidopsis thaliana in the Iberian Peninsula.The New phytologist · 2025Article
- Metabolome plasticity in 241 Arabidopsis thaliana accessions reveals evolutionary cold adaptation processes.Plant physiology · 2023Article
- Enzyme-treated chicory for cosmetics: application assessment and techno-economic analysis.AMB Express · 2022Article
- Comparative compositions of metabolites and dietary fibre components in doughs and breads produced from bread wheat, emmer and spelt and using yeast and sourdough processes.Food chemistry · 2022Article
- The influence of light microclimate on the lipid profile and associated transcripts of photosynthetically active grape berry seeds.Frontiers in plant science · 2022Article
- Metabolomics of Photosynthetically Active Tissues in White Grapes: Effects of Light Microclimate and Stress Mitigation Strategies.Metabolites · 2021Article
- Lignans of Sesame (Molecules (Basel, Switzerland) · 2021Review
- Metabotyping of 30 maize hybrids under early-sowing conditions reveals potential marker-metabolites for breeding.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Discovering variation of secondary metabolite diversity and its relationship with disease resistance inEcology and evolution · 2018Article
- Metabolic responses of Eucalyptus species to different temperature regimes.Journal of integrative plant biology · 2018Article
- Overexpression of AtWRKY50 is correlated with enhanced production of sinapic derivatives in Arabidopsis.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Arabidopsis myrosinases link the glucosinolate-myrosinase system and the cuticle.Scientific reports · 2016Article
- Natural variation of root exudates in Arabidopsis thaliana-linking metabolomic and genomic data.Scientific reports · 2016Article
- Analysis of plant leaf metabolites reveals no common response to insect herbivory by Pieris rapae in three related host-plant species.Journal of experimental botany · 2015Article
- Metabolic fingerprinting of Arabidopsis thaliana accessions.Frontiers in plant science · 2015Article
- Assessment of pleiotropic transcriptome perturbations in Arabidopsis engineered for indirect insect defence.BMC plant biology · 2014Article
- Dynamic metabolic and transcriptional profiling of Rhodococcus sp. strain YYL during the degradation of tetrahydrofuran.Applied and environmental microbiology · 2014Article
- Data Mining Methods for Omics and Knowledge of Crude Medicinal Plants toward Big Data Biology.Computational and structural biotechnology journal · 2013Review
- Metabolomic plasticity in GM and non-GM potato leaves in response to aphid herbivory and virus infection.Journal of agricultural and food chemistry · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolite fingerprinting is widely used to unravel the chemical characteristics of biological samples. Multivariate data analysis and other statistical tools are subsequently used to analyze and visualize the plasticity of the metabolome and/or the relationship between those samples. However, there are limitations to these approaches for example because of the multi-dimensionality of the data that makes interpretation of the data obtained from untargeted analysis almost impossible for an average human being. These limitations make the biological information that is of prime importance in untargeted studies be partially exploited. Even in the case of full exploitation, current methods for relationship elucidation focus mainly on between groups variation and differences. Therefore, a measure that is capable of exploiting both between- and within-group biological variation would be of great value. Here, we examined the natural variation in the metabolome of nine Arabidopsis thaliana accessions grown under various environmental conditions and established a measure for the metabolic distance between accessions and across environments. This data analysis approach shows that there is just a minor correlation between genetic and metabolic diversity of the nine accessions. On the other hand, it delivers so far in Arabidopsis unexplored chemical information and is shown to be biologically relevant for resistance studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11306-011-0375-3) contains supplementary material, which is available to authorized users.
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