SynthesisTheScientificWorldJournal2012
Antioxidants for preventing preeclampsia: a systematic review.
Synthesis in TheScientificWorldJournal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Pooled it
- Toxicology and teratology of the active ingredients of professional therapy MuscleCare products during pregnancy and lactation: a systematic review.BMC complementary and alternative medicine · 2015Pooled it
- Pooled it
- Paradoxes: Cholesterol and Hypoxia in Preeclampsia.Biomolecules · 2024Review
- An integral role of mitochondrial function in the pathophysiology of preeclampsia.Molecular biology reports · 2024Review
- Antioxidants in Pregnancy: Do We Really Need More Trials?Antioxidants (Basel, Switzerland) · 2022Review
- Review
- Dietary factors that affect the risk of pre-eclampsia.BMJ nutrition, prevention & health · 2022Review
- Placental Mitochondrial Abnormalities in Preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice.Molecular medicine reports · 2020Article
- Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Low Birth Weight, Blood Pressure and Renal Susceptibility.Current hypertension reports · 2019Review
- Serum Selenium Level in Early Healthy Pregnancy as a Risk Marker of Pregnancy Induced Hypertension.Nutrients · 2019Article
- Preeclampsia and intrauterine growth restriction: Role of human umbilical cord mesenchymal stem cells-trophoblast cross-talk.PloS one · 2019Article
- Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction.Oxidative medicine and cellular longevity · 2019Review
- Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery.Cell death & disease · 2018Article
- Phosphodiesterase Inhibition in the Treatment of Preeclampsia: What Is New?Current hypertension reports · 2018Review
- Mercury-induced Oxidative Stress May Adversely Affect Pregnancy Outcome among Dental Staff: A Cohort Study.The international journal of occupational and environmental medicine · 2018Article
- The effects of multi mineral-vitamin D and vitamins (C+E) supplementation in the prevention of preeclampsia: An RCT.International journal of reproductive biomedicine · 2017Article
- Maternal vitamin C deficiency during pregnancy results in transient fetal and placental growth retardation in guinea pigs.European journal of nutrition · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the efficacy of antioxidants for preventing preeclampsia and other maternal and fetal complications among pregnant women with low, moderate, or high risk of preeclampsia.
methodsWe searched MEDLINE, Embase, CENTRAL, mRCT, and other databases, with no language or publication restrictions. Two independent reviewers selected randomized controlled trials that evaluated the use of antioxidants versus placebo and extracted the relevant data. Relative risks (RRs) and 95% confidence intervals (95% CIs) were calculated. The data were compiled through the random effects model. MAIN
resultsFifteen studies were included (21,012 women and 21,647 fetuses). No statistically significant difference was found between women who received antioxidant treatment and women who received placebo for preeclampsia (RR = 0.92; 95% CI: 0.82-1.04), severe preeclampsia (RR = 1.03; 95% CI: 0.87-1.22), preterm birth (RR = 1.03; 95% CI: 0.94-1.14), and small for gestational age <10th centile (RR = 0.92; 95% CI: 0.80-1.05). Side effects were numerically more frequent in the antioxidants group compared to placebo, but without significant statistical difference (RR = 1.24; 95% CI: 0.85-1.80).
conclusionsThe available evidence reviewed does not support the use of antioxidants during pregnancy for the prevention of preeclampsia and other outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.