ArticleThe Journal of clinical endocrinology and metabolism2012
Brown adipose tissue and its relationship to bone structure in pediatric patients.
Article in The Journal of clinical endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- State of the art systematic review of bone disease in anorexia nervosa.The International journal of eating disorders · 2016Pooled it
- Ephedrine activates brown adipose tissue in lean but not obese humans.Diabetologia · 2013Trial
- The impact of obesity on bone health: molecular pathways, metabolic interactions, and associated pathologies.International journal of obesity (2005) · 2026Review
- Article
- Understanding neurodevelopmental proteasomopathies as new rare disease entities: A review of current concepts, molecular biomarkers, and perspectives.Genes & diseases · 2024Review
- Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9.iScience · 2024Article
- The complex pathophysiology of bone fragility in obesity and type 2 diabetes mellitus: therapeutic targets to promote osteogenesis.Frontiers in endocrinology · 2023Review
- Exploring the relationship of brown adipose tissue to bone microarchitecture using 7T MRI and micro-CT.Histology and histopathology · 2022Article
- Adipose tissue in bone regeneration - stem cell source and beyond.World journal of stem cells · 2022Review
- Thermogenic adipose tissue aging: Mechanisms and implications.Frontiers in cell and developmental biology · 2022Review
- Bone density and genomic analysis unfold cold adaptation mechanisms of ancient inhabitants of Tierra del Fuego.Scientific reports · 2021Article
- Brown Adipose Tissue: New Challenges for Prevention of Childhood Obesity. A Narrative Review.Nutrients · 2021Review
- Neurogenic heterotopic ossification in Guillain-Barre syndrome: a rare case report.Journal of musculoskeletal & neuronal interactions · 2020Article
- Obesity and Bone Health: A Complex Link.Frontiers in cell and developmental biology · 2020Review
- The Bones of Children With Obesity.Frontiers in endocrinology · 2020Review
- Article
- Association between brown adipose tissue and bone mineral density in humans.International journal of obesity (2005) · 2019Article
- The Impact of Childhood Obesity on Skeletal Health and Development.Journal of obesity & metabolic syndrome · 2019Review
- Relationship of Circulating Irisin with Body Composition, Physical Activity, and Cardiovascular and Metabolic Disorders in the Pediatric Population.International journal of molecular sciences · 2018Review
- Low temperature decreases bone mass in mice: Implications for humans.American journal of physical anthropology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
contextEmerging evidence suggests a possible link between brown adipose tissue (BAT) and bone metabolism.
objectiveThe objective of this study was to examine the relationships between BAT and bone cross-sectional dimensions in children and adolescents.
designThis was a cross-sectional study.
settingThe study was conducted at a pediatric referral center. PATIENTS: Patients included 40 children and teenagers (21 males and 19 females) successfully treated for pediatric malignancies.
interventionsThere were no interventions.
main outcome measuresThe volume of BAT was determined by fluorodeoxyglucose-positron emission tomography/computed tomography. Measures of the cross-sectional area and cortical bone area and measures of thigh musculature and sc fat were determined at the midshaft of the femur.
resultsRegardless of sex, there were significant correlations seen between BAT volume and the cross-sectional dimensions of the bone (r values between 0.68 and 0.77; all P ≤ 0 .001). Multiple regression analyses indicated that the volume of BAT predicted femoral cross-sectional area and cortical bone area, even after accounting for height, weight, and gender. The addition of muscle as an independent variable increased the predictive power of the model but significantly decreased the contribution of BAT.
conclusionsThe volume of BAT is positively associated with the amount of bone and the cross-sectional size of the femur in children and adolescents. This relation between BAT and bone structure could, at least in part, be mediated by muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.