ArticleGenome biology and evolution2012
Measuring microsatellite conservation in mammalian evolution with a phylogenetic birth-death model.
Article in Genome biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Birth-Death Dynamics of Microsatellites: Mechanistic Insights from Orthologous Loci in Felidae.Genes · 2025Article
- Article
- Article
- Novel implications of a strictly monomorphic (GCC) repeat in the human PRKACB gene.Scientific reports · 2021Article
- Massive variation of short tandem repeats with functional consequences across strains ofGenome research · 2018Article
- Genetic variations at the human growth hormone receptor (GHR) gene locus are associated with idiopathic short stature.Journal of cellular and molecular medicine · 2017Article
- Functional Mechanisms of Microsatellite DNA in Eukaryotic Genomes.Genome biology and evolution · 2017Review
- Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression.Translational psychiatry · 2017Article
- Microsatellite polymorphisms associated with human behavioural and psychological phenotypes including a gene-environment interaction.BMC medical genetics · 2017Article
- The mechanism of transactivation regulation due to polymorphic short tandem repeats (STRs) using IGF1 promoter as a model.Scientific reports · 2016Article
- Evolution of Nine Microsatellite Loci in the Fungus Fusarium oxysporum.Journal of molecular evolution · 2016Article
- Examining the role of components of Slc11a1 (Nramp1) in the susceptibility of New Zealand sea lions (Phocarctos hookeri) to disease.PloS one · 2015Article
- Remarkable selective constraints on exonic dinucleotide repeats.Evolution; international journal of organic evolution · 2014Article
- Patterns of microsatellite evolution inferred from the Helianthus annuus (Asteraceae) transcriptome.Journal of genetics · 2014Article
- STaRRRT: a table of short tandem repeats in regulatory regions of the human genome.BMC genomics · 2013Article
- Microsatellite tandem repeats are abundant in human promoters and are associated with regulatory elements.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microsatellites make up ∼3% of the human genome, and there is increasing evidence that some microsatellites can have important functions and can be conserved by selection. To investigate this conservation, we performed a genome-wide analysis of human microsatellites and measured their conservation using a binary character birth--death model on a mammalian phylogeny. Using a maximum likelihood method to estimate birth and death rates for different types of microsatellites, we show that the rates at which microsatellites are gained and lost in mammals depend on their sequence composition, length, and position in the genome. Additionally, we use a mixture model to account for unequal death rates among microsatellites across the human genome. We use this model to assign a probability-based conservation score to each microsatellite. We found that microsatellites near the transcription start sites of genes are often highly conserved, and that distance from a microsatellite to the nearest transcription start site is a good predictor of the microsatellite conservation score. An analysis of gene ontology terms for genes that contain microsatellites near their transcription start site reveals that regulatory genes involved in growth and development are highly enriched with conserved microsatellites.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.