ArticleCancer research2012
Numb regulates stability and localization of the mitotic kinase PLK1 and is required for transit through mitosis.
Article in Cancer research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Numb mitigates intestinal epithelial cell senescence induced by radiation through a PLK1-dependent pathway.Scientific reports · 2026Article
- Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanoma.NPJ precision oncology · 2024Article
- UBAP2L-dependent coupling of PLK1 localization and stability during mitosis.EMBO reports · 2023Article
- PAK2 is essential for chromosome alignment in metaphase I oocytes.Cell death & disease · 2023Article
- NUMB as a Therapeutic Target for Melanoma.The Journal of investigative dermatology · 2022Article
- PLK1 and NOTCH Positively Correlate in Melanoma and Their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways.Molecular cancer therapeutics · 2021Article
- Antileukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia.Molecular cancer therapeutics · 2019Article
- Article
- SIRT6 histone deacetylase functions as a potential oncogene in human melanoma.Genes & cancer · 2017Article
- Plk1 is essential for proper chromosome segregation during meiosis I/meiosis II transition in pig oocytes.Reproductive biology and endocrinology : RB&E · 2017Article
- Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma.Cancer letters · 2017Article
- Regulation of PTEN degradation and NEDD4-1 E3 ligase activity by Numb.Cell cycle (Georgetown, Tex.) · 2017Article
- Plk1 inhibition leads to a failure of mitotic division during the first mitotic division in pig embryos.Journal of assisted reproduction and genetics · 2017Article
- Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma.The Journal of investigative dermatology · 2016Article
- MLL5 maintains spindle bipolarity by preventing aberrant cytosolic aggregation of PLK1.The Journal of cell biology · 2016Article
- Mitotic Diversity in Homeostatic Human Interfollicular Epidermis.International journal of molecular sciences · 2016Article
- The tumor suppressive role of NUMB isoform 1 in esophageal squamous cell carcinoma.Oncotarget · 2014Article
- Identification of aurora kinase A as an unfavorable prognostic factor and potential treatment target for metastatic gastrointestinal stromal tumors.Oncotarget · 2014Article
- Novel downstream molecular targets of SIRT1 in melanoma: a quantitative proteomics approach.Oncotarget · 2014Article
- Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Numb functions in progenitor cell fate determination and early development, but it is also expressed in postdevelopmental tissues and cancers where its role is unclear. In this study, we report that a targeted knockdown of Numb expression causes a G(2)-M arrest and reduced cell growth in human melanoma cells. Co-immunoprecipitation and colocalization studies showed that Numb interacts with the serine/threonine polo-like kinase Plk1 and Numb cycles in a cell-cycle-dependent fashion along with this mitotic regulator. Interestingly, Numb expression was required for Plk1 protein stability and localization to the spindle poles during mitosis. Reduction in Numb expression resulted in mislocalization of Plk1 at both metaphase and anaphase, leading to disorganized γ-tubulin recruitment in centrosomes. Together, our findings present a novel function for Numb during symmetric cell division. We suggest that dysregulation of Numb expression results in mislocalized Plk1 and poor centrosomal γ-tubulin recruitment, potentially contributing to mitotic errors, aneuploidy, and cancer development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.