ArticleProceedings. Biological sciences2012
Disentangling the influence of parasite genotype, host genotype and maternal environment on different stages of bacterial infection in Daphnia magna.
Article in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Transcriptomic Landscape Reveals Immunity Related Trade-Offs in an Invertebrate-Fungal Host-Parasite System.Molecular ecology · 2026Article
- Why we need more individual-based parasite research.Parasites & vectors · 2026Review
- Pharmaceutical pollution alters the cost of bacterial infection and its relationship to pathogen load.Proceedings. Biological sciences · 2024Article
- Differential gene expression in response to fungal pathogen exposure in the aquatic invertebrate,Ecology and evolution · 2023Article
- Can pharmaceutical pollution alter the spread of infectious disease? A case study using fluoxetine.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Warmer temperatures limit the effects of antidepressant pollution on life-history traits.Proceedings. Biological sciences · 2022Article
- Between virus correlations in the outcome of infection across host species: Evidence of virus by host species interactions.Evolution letters · 2021Article
- Higher mortality of the less suitable brown trout host compared to the principal Atlantic salmon host when infested with freshwater pearl mussel (Margaritifera margaritifera) glochidia.Parasitology research · 2021Article
- Temperature and pathogen exposure act independently to drive host phenotypic trajectories.Biology letters · 2021Article
- Patterns of Sphaeridiotrema pseudoglobulus infection in sympatric and allopatric hosts (Bithynia tentaculata) originating from widely separated sites across the USA.Parasitology research · 2021Article
- Disentangling non-specific and specific transgenerational immune priming components in host-parasite interactions.Proceedings. Biological sciences · 2020Article
- Independent effects on cellular and humoral immune responses underlie genotype-by-genotype interactions between Drosophila and parasitoids.PLoS pathogens · 2019Article
- Infection in patchy populations: Contrasting pathogen invasion success and dispersal at varying times since host colonization.Evolution letters · 2019Article
- Maternal Stress Reduces the Susceptibility of Root-Knot Nematodes toJournal of nematology · 2019Article
- Linking sex differences to the evolution of infectious disease life-histories.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- The impact of host sex on the outcome of co-infection.Scientific reports · 2017Article
- The trans-generational impact of population density signals on host-parasite interactions.BMC evolutionary biology · 2016Article
- Below-ground abiotic and biotic heterogeneity shapes above-ground infection outcomes and spatial divergence in a host-parasite interaction.The New phytologist · 2015Article
- Expression of parasite genetic variation changes over the course of infection: implications of within-host dynamics for the evolution of virulence.Proceedings. Biological sciences · 2015Article
- Genetic architecture of resistance in Daphnia hosts against two species of host-specific parasites.Heredity · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals naturally vary in the severity of infectious disease when exposed to a parasite. Dissecting this variation into genetic and environmental components can reveal whether or not this variation depends on the host genotype, parasite genotype or a range of environmental conditions. Complicating this task, however, is that the symptoms of disease result from the combined effect of a series of events, from the initial encounter between a host and parasite, through to the activation of the host immune system and the exploitation of host resources. Here, we use the crustacean Daphnia magna and its parasite Pasteuria ramosa to show how disentangling genetic and environmental factors at different stages of infection improves our understanding of the processes shaping infectious disease. Using compatible host-parasite combinations, we experimentally exclude variation in the ability of a parasite to penetrate the host, from measures of parasite clearance, the reduction in host fecundity and the proliferation of the parasite. We show how parasite resistance consists of two components that vary in environmental sensitivity, how the maternal environment influences all measured aspects of the within-host infection process and how host-parasite interactions following the penetration of the parasite into the host have a distinct temporal component.
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