Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Connectivity changes underlying spectral EEG changes during propofol-induced loss of consciousness.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
164 citing papers in PubMed, 1 synthesis or guideline pooled it, 314 citations in OpenAlex.
- A methodological guideline for consciousness assessment via neural electrophysiological activity.Military Medical Research · 2025Guideline
- Detection of Electrophysiological Activity of Amygdala during Anesthesia Using Stereo-EEG: A Preliminary Research in Anesthetized Epileptic Patients.BioMed research international · 2020Trial
- Disruption of posteromedial large-scale neural communication predicts recovery from coma.Neurology · 2015Trial
- Directional connectivity between frontal and posterior brain regions is altered with increasing concentrations of propofol.PloS one · 2014Trial
- BOLD fMRI in infants under sedation: Comparing the impact of pentobarbital and propofol on auditory and language activation.Journal of magnetic resonance imaging : JMRI · 2013Trial
- Electroencephalogram signatures of loss and recovery of consciousness from propofol.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Reorganization of Human Brain Waves Across Diverse States of Consciousness.bioRxiv : the preprint server for biology · 2026Article
- Esketamine Preserves Network Connectivity and Promotes Recovery in Consciousness Disorders.CNS neuroscience & therapeutics · 2026Article
- Auricular transcutaneous vagus nerve stimulation alters directed cortical communication during intentional actions.iScience · 2026Article
- Neurophysiological connectomic signatures of consciousness during propofol-induced general anesthesia.Cell reports. Medicine · 2026Article
- Deviations in effective connectivity explain different hallucination subtypes in Parkinson's disease psychosis.Nature. Mental health · 2026Article
- Windows to Consciousness: The Role of Fronto-Parietal Connectivity in Anesthesia-Induced Unconsciousness.Current neuropharmacology · 2026Review
- Wakefulness can be distinguished from general anesthesia and sleep in flies using a massive library of univariate time series analyses.PLoS biology · 2025Article
- A reduction in energy costs induces integrated states of brain dynamics.Scientific reports · 2025Article
- Accurate Machine Learning-based Monitoring of Anesthesia Depth with EEG Recording.Neuroscience bulletin · 2025Article
- Cortical direction selectivity increases from the input to the output layers of visual cortex.PLoS biology · 2025Article
- Neural Network Mechanisms Underlying General Anesthesia: Cortical and Subcortical Nuclei.Neuroscience bulletin · 2024Review
- Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium.BJA open · 2024Article
- Anesthetic effects on electrophysiological responses across the visual pathway.Scientific reports · 2024Article
- Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
104 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
The mechanisms underlying anesthesia-induced loss of consciousness remain a matter of debate. Recent electrophysiological reports suggest that while initial propofol infusion provokes an increase in fast rhythms (from beta to gamma range), slow activity (from delta to alpha range) rises selectively during loss of consciousness. Dynamic causal modeling was used to investigate the neural mechanisms mediating these changes in spectral power in humans. We analyzed source-reconstructed data from frontal and parietal cortices during normal wakefulness, propofol-induced mild sedation, and loss of consciousness. Bayesian model selection revealed that the best model for explaining spectral changes across the three states involved changes in corticothalamic interactions. Compared with wakefulness, mild sedation was accounted for by an increase in thalamic excitability, which did not further increase during loss of consciousness. In contrast, loss of consciousness per se was accompanied by a decrease in backward corticocortical connectivity from frontal to parietal cortices, while thalamocortical connectivity remained unchanged. These results emphasize the importance of recurrent corticocortical communication in the maintenance of consciousness and suggest a direct effect of propofol on cortical dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.