ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Light-driven calcium signals in mouse cone photoreceptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Single-Cell Transcriptomic Profiling in Inherited Retinal Degeneration Reveals Distinct Metabolic Pathways in Rod and Cone Photoreceptors.International journal of molecular sciences · 2022Article
- Redefining the role of CaCell death & disease · 2022Article
- HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice.Cell death and differentiation · 2021Article
- Neural circuits in the mouse retina support color vision in the upper visual field.Nature communications · 2020Article
- Circadian regulation in the retina: From molecules to network.The European journal of neuroscience · 2020Review
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- Broad spectrum metabolomics for detection of abnormal metabolic pathways in a mouse model for retinitis pigmentosa.Experimental eye research · 2019Article
- Electrical activation of degenerated photoreceptors in blind mouse retina elicited network-mediated responses in different types of ganglion cells.Scientific reports · 2018Article
- Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration.Scientific reports · 2016Article
- A new role for AMP-activated protein kinase in the circadian regulation of L-type voltage-gated calcium channels in late-stage embryonic retinal photoreceptors.Journal of neurochemistry · 2015Article
- Imaging Ca2+ dynamics in cone photoreceptor axon terminals of the mouse retina.Journal of visualized experiments : JoVE · 2015Article
- Differential regulation of cone calcium signals by different horizontal cell feedback mechanisms in the mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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- Synaptic remodeling generates synchronous oscillations in the degenerated outer mouse retina.Frontiers in neural circuits · 2014Article
- Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms.Cell death & disease · 2013Article
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Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium mediates various neuronal functions. The complexity of neuronal Ca²⁺ signaling is well exemplified by retinal cone photoreceptors, which, with their distinct compartmentalization, offer unique possibilities for studying the diversity of Ca²⁺ functions in a single cell. Measuring subcellular Ca²⁺ signals in cones under physiological conditions is not only fundamental for understanding cone function, it also bears important insights into pathophysiological processes governing retinal neurodegeneration. However, due to the proximity of light-sensitive outer segments to other cellular compartments, optical measurements of light-evoked Ca²⁺ responses in cones are challenging. We addressed this problem by generating a transgenic mouse (HR2.1:TN-XL) in which both short- and middle-wavelength-sensitive cones selectively express the genetically encoded ratiometric Ca²⁺ biosensor TN-XL. We show that HR2.1:TN-XL allows recording of light-evoked Ca²⁺ responses using two-photon imaging in individual cone photoreceptor terminals and to probe phototransduction and its diverse regulatory mechanisms with pharmacology at subcellular resolution. To further test this system, we asked whether the classical, nitric oxide (NO)-soluble guanylyl-cyclase (sGC)-cGMP pathway could modulate Ca²⁺ in cone terminals. Surprisingly, NO reduced Ca²⁺ resting levels in mouse cones, without evidence for direct sGC involvement. In conclusion, HR2.1:TN-XL mice offer unprecedented opportunities to elucidate light-driven Ca²⁺ dynamics and their (dys)regulation in cone photoreceptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.