ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Genetic analysis of ecdysis behavior in Drosophila reveals partially overlapping functions of two unrelated neuropeptides.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 64 citations in OpenAlex.
- Phase-Resolved Pupal Ecdysis Behavior and Requirement of Ecdysis-Triggering Hormone in Henosepilachna vigintioctomaculata.Archives of insect biochemistry and physiology · 2026Article
- Article
- Genomic and phylogenetic insights for three species of thrips (Thysanoptera: Terebrantia) associated with Colombian avocado.Journal of insect science (Online) · 2026Article
- Characterization of eclosion hormone receptor function reveals differential hormonal control of ecdysis during Drosophila development.PLoS genetics · 2025Article
- Characterization Eclosion Hormone Receptor function reveals differential hormonal control of ecdysis duringbioRxiv : the preprint server for biology · 2025Article
- Neuromodulation and the toolkit for behavioural evolution: can ecdysis shed light on an old problem?The FEBS journal · 2024Review
- A cell atlas of the larval Aedes aegypti ventral nerve cord.Neural development · 2024Article
- Extracting temporal relationships between weakly coupled peptidergic and motoneuronal signaling: Application to Drosophila ecdysis behavior.PLoS computational biology · 2021Article
- Neonicotinoids can cause arrested pupal ecdysis in Lepidoptera.Scientific reports · 2021Article
- Pupal behavior emerges from unstructured muscle activity in response to neuromodulation ineLife · 2021Article
- Identification and function of ETH receptor networks in the silkworm Bombyx mori.Scientific reports · 2021Article
- Bilberry (Antioxidants (Basel, Switzerland) · 2020Article
- CCAP regulates feeding behavior via the NPF pathway inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- The tanning hormone, bursicon, does not act directly on the epidermis to tan the Drosophila exoskeleton.BMC biology · 2020Article
- Article
- A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila.Cell metabolism · 2019Article
- Alternative cleavage of the bone morphogenetic protein (BMP), Gbb, produces ligands with distinct developmental functions and receptor preferences.The Journal of biological chemistry · 2017Article
- Article
- Endocrine network essential for reproductive success inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ecdysis behavior allows insects to shed their old exoskeleton at the end of every molt. It is controlled by a suite of interacting hormones and neuropeptides, and has served as a useful behavior for understanding how bioactive peptides regulate CNS function. Previous findings suggest that crustacean cardioactive peptide (CCAP) activates the ecdysis motor program; the hormone bursicon is believed to then act downstream of CCAP to inflate, pigment, and harden the exoskeleton of the next stage. However, the exact roles of these signaling molecules in regulating ecdysis remain unclear. Here we use a genetic approach to investigate the functions of CCAP and bursicon in Drosophila ecdysis. We show that null mutants in CCAP express no apparent defects in ecdysis and postecdysis, producing normal adults. By contrast, a substantial fraction of flies genetically null for one of the two subunits of bursicon [encoded by the partner of bursicon gene (pburs)] show severe defects in ecdysis, with escaper adults exhibiting the expected failures in wing expansion and exoskeleton pigmentation and hardening. Furthermore, flies lacking both CCAP and bursicon show much more severe defects at ecdysis than do animals null for either neuropeptide alone. Our results show that the functions thought to be subserved by CCAP are partially effected by bursicon, and that bursicon plays an important and heretofore undescribed role in ecdysis behavior itself. These findings have important implications for understanding the regulation of this vital insect behavior and the mechanisms by which hormones and neuropeptides control the physiology and behavior of animals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.