Evidence map›Paper›PMID 22592980›Full record

ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2012

The evolution of dynamin to regulate clathrin-mediated endocytosis: speculations on the evolutionarily late appearance of dynamin relative to clathrin-mediated endocytosis.

Ya-Wen Liu, Andrew I Su, Sandra L Schmid

Open access · bronzeAbstract read
In one paragraph

Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. On the existence of endocytosis driven by membrane phase separations.Biochimica et biophysica acta. Biomembranes · 2020
    Review
  3. Dynamin 2 (DNM2) as Cause of, and Modifier for, Human Neuromuscular Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018
    Review
  4. Regulation of Clathrin-Mediated Endocytosis.Annual review of biochemistry · 2018
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Ancient dynamin segments capture early stages of host-mitochondrial integration.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  10. Tetrahymena thermophila: a divergent perspective on membrane traffic.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2014
    Review
  11. Article
  12. Expanding proteostasis by membrane trafficking networks.Cold Spring Harbor perspectives in biology · 2013
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ya-Wen LiuDepartment of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA.
Andrew I Su
Sandra L Schmid
Scripps Research Institute · US

Funding

EARLY STEPS IN RECEPTOR-MEDIATED ENDOCYTOSISR01GM042455 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI METTLEN, MARCEL BERNARD · 1989 to 2020
$8.2M
The Clathrin Coated Vesicle CycleR01MH061345 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI SCHMID, SANDRA L. · 2010 to 2019
$5.0M
THE CLATHRIN COATED VESICLE CYCLER37MH061345 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI SCHMID, SANDRA L. · 2000 to 2009
$4.7M
NIGMS NIH HHS GM42455NIGMS NIH HHS R01 GM042455NIMH NIH HHS MH61345NIMH NIH HHS R01 MH061345NIMH NIH HHS R37 MH061345
6 · The paper itself

Abstract

Whereas clathrin-mediated endocytosis (CME) exists in all eukaryotic cells, we first detect classical dynamin in Ichthyosporid, a single-cell, metazoan precursor. Based on a key functional residue in its pleckstrin homology domain, we speculate that the evolution of metazoan dynamin coincided with the specialized need for regulated CME during neurotransmission.

Indexed as

EndocytosisEvolution, MolecularAmino Acid SequenceAnimalsBlood ProteinsClathrinDynaminsHumansMolecular Sequence DataNeuronsOrgan SpecificityPhosphoproteinsPhylogenyProtein IsoformsProtein Structure, TertiarySequence Homology, Amino AcidBlood ProteinsClathrinDynaminsPhosphoproteinsplatelet protein P47Protein Isoforms

Identifiers

PMID22592980
PMCPMC5715466
OpenAlexW1899641772

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.