Evidence map›Paper›PMID 22592957›Full record

ReviewArchives of virology2012

The contribution of rodent models to the pathological assessment of flaviviral infections of the central nervous system.

David C Clark, Aaron C Brault, Elizabeth Hunsperger

Abstract readReview
In one paragraph

Review in Archives of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Co-infection dynamics ofInfection and immunity · 2024
    Article
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  17. Frontiers in cellular and infection microbiology · 2019
    Review
  18. Article
  19. Zika Virus Infection in Syrian Golden Hamsters and Strain 13 Guinea Pigs.The American journal of tropical medicine and hygiene · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

David C ClarkCenter for Vectorborne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis 95616, USA. dcclark@ucdavis.edu
Aaron C Brault
Elizabeth Hunsperger
Centers for Disease Control and Prevention · USUniversity of California System · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

Members of the genus Flavivirus are responsible for a spectrum of important neurological syndromes in humans and animals. Rodent models have been used extensively to model flavivirus neurological disease, to discover host-pathogen interactions that influence disease outcome, and as surrogates to determine the efficacy and safety of vaccines and therapeutics. In this review, we discuss the current understanding of flavivirus neuroinvasive disease and outline the host, viral and experimental factors that influence the outcome and reliability of virus infection of small-animal models.

Indexed as

Disease Models, AnimalEncephalitis, ViralFlavivirus InfectionsRodentiaAnimalsCentral Nervous SystemCricetinaeFlavivirusHost-Pathogen InteractionsInsect VectorsMice

Identifiers

PMID22592957
PMCPMC4581843
OpenAlexW2041689872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.