SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis.
Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Review
- Janus kinase inhibitors in systemic lupus erythematosus: implications for tyrosine kinase 2 inhibition.Frontiers in medicine · 2023Review
- Association of TYK2 polymorphisms with autoimmune diseases: A comprehensive and updated systematic review with meta-analysis.Genetics and molecular biology · 2021Article
- [Psoriatic arthritis : Drugs of the (near) future].Zeitschrift fur Rheumatologie · 2017Review
- [Update on kinase inhibitors].Zeitschrift fur Rheumatologie · 2016Review
- Article
- The role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets.Expert review of clinical immunology · 2014Review
- Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations.Current genomics · 2014Article
- Genetics of the type I interferon pathway in systemic lupus erythematosus.International journal of clinical rheumatology · 2013Article
- Genetics of SLE: functional relevance for monocytes/macrophages in disease.Clinical & developmental immunology · 2012Review
- Single Nucleotide Polymorphism ofAvicenna journal of medical biotechnologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to determine whether phox homology domain containing serine/threonine kinase (PXK) and tyrosine kinase 2 (TYK2) confer susceptibility to systemic lupus erythematosus (SLE). MATERIALS AND
methodsThe authors conducted meta-analyses on associations between SLE susceptibility and the rs6445975 polymorphism of PXK and the rs2304256, rs12720270, rs280519, and rs1272036 polymorphisms of TYK2.
resultsA total of 13 separate comparisons studies were included in this meta-analysis. Meta-analysis identified an association between SLE and the 2 allele of the rs6445975 polymorphism in the overall population [odds ratio (OR) = 1.151, 95 % confidence interval (CI) = 1.086-1.291, P = 1.8E-06]. Stratification by ethnicity identified a significant association between this polymorphism and SLE in Europeans (OR = 1.198, 95 % CI = 1.118-1.285, P = 3.4E-07), but not in Asians. Meta-analysis identified a significant negative association between SLE and the 2 allele of the rs2304256 polymorphism in the overall population (OR = 0.808, 95 % CI = 0.659-0.990, P = 0.040), and a significant negative association was found in Europeans, but not in Asians.
conclusionsThis meta-analysis shows that the rs6445975 polymorphism of PXK and the rs2304256 polymorphism of TYK2 are associated with the development of SLE in Europeans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.