ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Association of promoter region single nucleotide polymorphisms at positions -819C/T and -592C/A of interleukin 10 gene with ischemic heart disease.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Association of IL-10-1082A/G polymorphism with cardiovascular disease risk: Evidence from a case-control study to an updated meta-analysis.Molecular genetics & genomic medicine · 2019Pooled it
- Pooled it
- IL10 promoter variants are associated with gene expression but they are not markers of susceptibility to acute coronary syndrome.Scientific reports · 2024Article
- Lack of Association between Cytokine Genetic Polymorphisms in Takayasu's Arteritis in Mexican Patients.International journal of environmental research and public health · 2019Article
- Inflammation-related genes are associated with epigenetic aging in HIV.Journal of neurovirology · 2019Article
- Interleukin-10 and Transforming Growth Factor Beta1 Gene Polymorphisms in Chronic Heart Failure.Acta bio-medica : Atenei Parmensis · 2019Article
- Association between IL-10 gene polymorphisms and the risk of ischemic stroke in a Chinese population.International journal of clinical and experimental pathology · 2015Article
- Association between three interleukin-10 gene polymorphisms and coronary artery disease risk: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIschemic heart disease (IHD) is a disease characterized by ischemia of the heart muscle, usually due to coronary artery disease. Interleukin-10 (IL10) is a proinflammatory cytokine known to protect endothelial function. In this study, we investigated the association of promoter region polymorphisms of the IL10 gene with IHD.
methodsWe recruited 313 control and 173 IHD patients. The selected SNPs in IL10 were genotyped using pyrosequencing.
resultsSNPs at positions -592C/A and -819C/T were statistically associated with IHD (P = 0.014 and P = 0.037). Similarly, the mean value of C-reactive protein in the C allele at -592C/A and -819C/T was significantly higher than that in the A allele at -592C/A (P = 0.026) and T allele at -819C/T (P = 0.026). The presence of hypertension in the C allele at -592C/A and -819C/T was significantly more frequent than that in the A allele at -592C/A (P = 0.044) and T allele at -819C/T (P = 0.044). In the haplotype of two SNPs (-592C/A and -819C/T), one haplotype (CC) presented an association with IHD (P = 0.012).
conclusionsThese results indicate that the C allele with SNPs at position -592C/A and -819C/T of IL10 gene may be associated with IHD in the Korean population.
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