ArticleThe Journal of comparative neurology2012
Melanocortin-4 receptor expression in different classes of spinal and vagal primary afferent neurons in the mouse.
Article in The Journal of comparative neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Neuromodulation using Bioelectronics-enabled therapies to combat insulin resistance and its comorbidities.Journal of diabetes and metabolic disorders · 2026Review
- Article
- Endogenous cannabinoids are required for MC4R-mediated control of energy homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Detection of G Protein-coupled Receptor Expression in Mouse Vagal Afferent Neurons using Multiplex In Situ Hybridization.Journal of visualized experiments : JoVE · 2021Article
- Gut-brain communication and obesity: understanding functions of the vagus nerve.The Journal of clinical investigation · 2021Review
- Hypothalamic Pomc Neurons Innervate the Spinal Cord and Modulate the Excitability of Premotor Circuits.Current biology : CB · 2020Article
- Neuroanatomy of melanocortin-4 receptor pathway in the mouse brain.Open life sciences · 2020Article
- Vagal mechanisms as neuromodulatory targets for the treatment of metabolic disease.Annals of the New York Academy of Sciences · 2019Review
- Melanocortin Receptor 4 Signaling Regulates Vertebrate Limb Regeneration.Developmental cell · 2018Article
- NaMolecular metabolism · 2017Review
- Melanocortin-4 receptor expression in autonomic circuitry involved in gastric function.International journal of clinical and experimental medicine · 2015Article
- Central vagal afferent endings mediate reduction of food intake by melanocortin-3/4 receptor agonist.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Effects of a novel MC4R agonist on maintenance of reduced body weight in diet-induced obese mice.Obesity (Silver Spring, Md.) · 2014Article
- Synaptic changes induced by melanocortin signalling.Nature reviews. Neuroscience · 2014Review
- Molecular anatomy of the gut-brain axis revealed with transgenic technologies: implications in metabolic research.Frontiers in neuroscience · 2013Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Melanocortin-4 receptor (MC4R) ligands are known to modulate nociception, but the site of action of MC4R signaling on nociception remains to be elucidated. The current study investigated MC4R expression in dorsal root ganglia (DRG) of the MC4R-GFP reporter mouse. Because MC4R is known to be expressed in vagal afferent neurons in the nodose ganglion (NG), we also systematically compared MC4R-expressing vagal and spinal afferent neurons. Abundant green fluorescent protein (GFP) immunoreactivity was found in about 45% of DRG neuronal profiles (at the mid-thoracic level), the majority being small-sized profiles. Immunohistochemistry combined with in situ hybridization confirmed that GFP was genuinely produced in MC4R-expressing neurons in the DRG. While a large number of GFP profiles in the DRG coexpressed Nav1.8 mRNA (84%) and bound isolectin B4 (72%), relatively few GFP profiles were positive for NF200 (16%) or CGRP (13%), suggesting preferential MC4R expression in C-fiber nonpeptidergic neurons. By contrast, GFP in the NG frequently colocalized with Nav1.8 mRNA (64%) and NF200 (29%), but only to a moderate extent with isolectin B4 (16%). Lastly, very few GFP profiles in the NG expressed CGRP (5%) or CART (4%). Together, our findings demonstrate variegated MC4R expression in different classes of vagal and spinal primary afferent neurons, and underscore the role of the melanocortin system in modulating nociceptive and nonnociceptive peripheral sensory modalities.
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