SynthesisThe Cochrane database of systematic reviews2012
Clonazepam for neuropathic pain and fibromyalgia in adults.
Synthesis in The Cochrane database of systematic reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 13 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews.The Cochrane database of systematic reviews · 2023Pooled it
- Oxcarbazepine for neuropathic pain.The Cochrane database of systematic reviews · 2017Pooled it
- A systematic review of the effectiveness of policies restricting access to pregabalin.BMC health services research · 2017Pooled it
- Benzodiazepines for restless legs syndrome.The Cochrane database of systematic reviews · 2017Pooled it
- Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data.The journal of pain · 2015Pooled it
- Gabapentin for chronic neuropathic pain and fibromyalgia in adults.The Cochrane database of systematic reviews · 2014Pooled it
- Carbamazepine for chronic neuropathic pain and fibromyalgia in adults.The Cochrane database of systematic reviews · 2014Pooled it
- The efficacy of duloxetine, non-steroidal anti-inflammatory drugs, and opioids in osteoarthritis: a systematic literature review and meta-analysis.BMC musculoskeletal disorders · 2014Pooled it
- Lamotrigine for chronic neuropathic pain and fibromyalgia in adults.The Cochrane database of systematic reviews · 2013Pooled it
- Antiepileptic drugs for neuropathic pain and fibromyalgia - an overview of Cochrane reviews.The Cochrane database of systematic reviews · 2013Pooled it
- Topiramate for neuropathic pain and fibromyalgia in adults.The Cochrane database of systematic reviews · 2013Pooled it
- Phenytoin for neuropathic pain and fibromyalgia in adults.The Cochrane database of systematic reviews · 2012Pooled it
- Lacosamide for neuropathic pain and fibromyalgia in adults.The Cochrane database of systematic reviews · 2012Pooled it
- Trial
- Therapeutic and research frontiers in fibromyalgia: integrating pathophysiology with innovative drug repurposing.Inflammopharmacology · 2026Review
- Effects of different anesthetics on remifentanil-induced postinfusion hyperalgesia in patients undergoing percutaneous endoscopic interlaminar discectomy: a randomized controlled trial.Frontiers in medicine · 2025Article
- Pharmacological Treatment of Fibromyalgia Syndrome: A Practice-Based Review.Current pain and headache reports · 2024Review
- Longitudinal cytokine and multi-modal health data of an extremely severe ME/CFS patient with HSD reveals insights into immunopathology, and disease severity.Frontiers in immunology · 2024Article
- Therapeutic Approach for Trigeminal Neuralgia: A Systematic Review.Biomedicines · 2023Review
- Pharmacological Proposal Approach to Managing Chronic Pain Associated with COVID-19.Biomedicines · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntiepileptic drugs have been used in pain management since the 1960s; some have shown efficacy in treating different neuropathic pain conditions. Clonazepam, a benzodiazepine, is an established antiepileptic drug, but its place in the treatment of neuropathic pain is unclear.
objectivesTo assess the analgesic efficacy and adverse effects of the antiepileptic drug clonazepam in neuropathic pain and fibromyalgia. SEARCH
methodsWe searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 2). MEDLINE, and EMBASE to 28 February 2012, together with reference lists of retrieved papers and reviews, and ClinicalTrials.gov. SELECTION CRITERIA: We planned to include randomised, double-blind studies of eight weeks duration or longer, comparing clonazepam with placebo or another active treatment in chronic neuropathic pain or fibromyalgia. DATA COLLECTION AND ANALYSIS: Two review authors would independently extract data for efficacy and adverse events, and examine issues of study quality. MAIN
resultsWe did not identify any studies that satisfied the inclusion criteria. AUTHORS'
conclusionsThis review uncovered no evidence of sufficient quality to support the use of clonazepam in chronic neuropathic pain or fibromyalgia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.