SynthesisThe Cochrane database of systematic reviews2012
Phenytoin for neuropathic pain and fibromyalgia in adults.
Synthesis in The Cochrane database of systematic reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 12 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews.The Cochrane database of systematic reviews · 2023Pooled it
- Oxcarbazepine for neuropathic pain.The Cochrane database of systematic reviews · 2017Pooled it
- Pain management strategies for neuropathic pain in Fabry disease--a systematic review.BMC neurology · 2016Pooled it
- Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data.The journal of pain · 2015Pooled it
- Gabapentin for chronic neuropathic pain and fibromyalgia in adults.The Cochrane database of systematic reviews · 2014Pooled it
- Carbamazepine for chronic neuropathic pain and fibromyalgia in adults.The Cochrane database of systematic reviews · 2014Pooled it
- Resistance exercise training for fibromyalgia.The Cochrane database of systematic reviews · 2013Pooled it
- Lamotrigine for chronic neuropathic pain and fibromyalgia in adults.The Cochrane database of systematic reviews · 2013Pooled it
- Antiepileptic drugs for neuropathic pain and fibromyalgia - an overview of Cochrane reviews.The Cochrane database of systematic reviews · 2013Pooled it
- Topiramate for neuropathic pain and fibromyalgia in adults.The Cochrane database of systematic reviews · 2013Pooled it
- Clonazepam for neuropathic pain and fibromyalgia in adults.The Cochrane database of systematic reviews · 2012Pooled it
- Lacosamide for neuropathic pain and fibromyalgia in adults.The Cochrane database of systematic reviews · 2012Pooled it
- Metabotropic Glutamate Receptor 5: A Potential Target for Neuropathic Pain Treatment.Current neuropharmacology · 2025Review
- Evidence-based guideline on chronic postsurgical pain management in adult patients in resource-restricted setting, 2023: systematic review and guideline.Annals of medicine and surgery (2012) · 2023Article
- Therapeutic Approach for Trigeminal Neuralgia: A Systematic Review.Biomedicines · 2023Review
- Pharmacological Proposal Approach to Managing Chronic Pain Associated with COVID-19.Biomedicines · 2023Review
- Prevention and Management Strategies for Diabetic Neuropathy.Life (Basel, Switzerland) · 2022Review
- Guideline "diagnosis and non interventional therapy of neuropathic pain" of the German Society of Neurology (deutsche Gesellschaft für Neurologie).Neurological research and practice · 2020Article
- Impact of Polypharmacy on Candidate Biomarker miRNomes for the Diagnosis of Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Striking Back on Treatments.Pharmaceutics · 2019Article
- Phenytoin and carbamazepine in trigeminal neuralgia: marketing-based versus evidence-based treatment.Journal of pain research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntiepileptic drugs have been used in pain management since the 1960s; some have shown efficacy in treating different neuropathic pain conditions. Phenytoin is an established antiepileptic drug that has been used occasionally to treat intractable trigeminal neuralgia.
objectivesTo assess the analgesic efficacy and adverse effects of the antiepileptic drug phenytoin in neuropathic pain and fibromyalgia. SEARCH
methodsWe searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 2), MEDLINE, and EMBASE to 28 February 2012, together with reference lists of retrieved papers and reviews, and ClinicalTrials.gov. SELECTION CRITERIA: We planned to include randomised, double-blind studies of eight weeks duration or longer, comparing phenytoin with placebo or another active treatment in chronic neuropathic pain or fibromyalgia. DATA COLLECTION AND ANALYSIS: Two review authors would independently extract data for efficacy and adverse events, and examine issues of study quality. MAIN
resultsWe did not identify any studies that satisfied the inclusion criteria. AUTHORS'
conclusionsThis review uncovered no evidence of sufficient quality to support the use of phenytoin in chronic neuropathic pain or fibromyalgia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.