ArticleAmerican journal of physiology. Renal physiology2012
High Na intake increases renal angiotensin II levels and reduces expression of the ACE2-AT(2)R-MasR axis in obese Zucker rats.
Article in American journal of physiology. Renal physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Panax ginseng suppresses endothelin-1-induced cardiomyocyte hypertrophy through inhibition of the local angiotensin II-AT1 receptor signaling axis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- The Role of Renal Na+/H+ Exchange in the Regulation of Acid-Base and Sodium Homeostasis in Premature Infants.Physiological research · 2026Review
- Increased sodium content after saltwater washing did not compromise the attenuation of blood pressure increase by cod backbone proteins in obese ZuckerJournal of nutritional science · 2026Article
- Angiotensin-II type 2 receptor-mediated renoprotection is independent of receptor Mas in obese Zucker rats fed high-sodium diet.Frontiers in pharmacology · 2024Article
- Inverse Salt Sensitivity of Blood Pressure: Mechanisms and Potential Relevance for Prevention of Cardiovascular Disease.Current hypertension reports · 2022Review
- New perspectives on angiotensin-converting enzyme 2 and its related diseases.World journal of diabetes · 2021Review
- Angiotensin-(1-7)-A Potential Remedy for AKI: Insights Derived from the COVID-19 Pandemic.Journal of clinical medicine · 2021Review
- Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake.Frontiers in pharmacology · 2021Article
- Angiotensin-(1-7) inhibits sodium transport via Mas receptor by increasing nitric oxide production in thick ascending limb.Physiological reports · 2019Article
- Relationships between urinary electrolytes excretion and central hemodynamics, and arterial stiffness in hypertensive patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin II type 2 receptor/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2016Article
- Angiotensin II Type 2-Receptor Agonist C21 Reduces Proteinuria and Oxidative Stress in Kidney of High-Salt-Fed Obese Zucker Rats.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Plasma Vitamin D Level and Change in Albuminuria and eGFR According to Sodium Intake.Clinical journal of the American Society of Nephrology : CJASN · 2015Observational
- Angiotensin AT2 receptor agonist prevents salt-sensitive hypertension in obese Zucker rats.American journal of physiology. Renal physiology · 2015Article
- Review
- Brain endogenous angiotensin II receptor type 2 (AT2-R) protects against DOCA/salt-induced hypertension in female rats.Journal of neuroinflammation · 2015Article
- Oxidative stress causes imbalance of renal renin angiotensin system (RAS) components and hypertension in obese Zucker rats.Journal of the American Heart Association · 2015Article
- ACE and ACE2 in kidney disease.World journal of nephrology · 2015Review
- Urinary sodium excretion has positive correlation with activation of urinary renin angiotensin system and reactive oxygen species in hypertensive chronic kidney disease.Journal of Korean medical science · 2014Article
- ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury.Current hypertension reports · 2014Review
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5 authors at 2 institutions in 1 country.
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Abstract
High sodium intake is known to regulate the renal renin-angiotensin system (RAS) and is a risk factor for the pathogenesis of obesity-related hypertension. The complex nature of the RAS reveals that its various components may have opposing effects on natriuresis and blood pressure regulation. We hypothesized that high sodium intake differentially regulates and shifts a balance between opposing components of the renal RAS, namely, angiotensin-converting enzyme (ACE)-ANG II-type 1 ANG II receptor (AT(1)R) vs. AT(2)-ACE2-angiotensinogen (Ang) (1-7)-Mas receptor (MasR), in obesity. In the present study, we evaluated protein and/or mRNA expression of angiotensinogen, renin, AT(1A/B)R, ACE, AT(2)R, ACE2, and MasR in the kidney cortex following 2 wk of a 8% high-sodium (HS) diet in lean and obese Zucker rats. The expression data showed that the relative expression pattern of ACE and AT(1B)R increased, renin decreased, and ACE2, AT(2)R, and MasR remained unaltered in HS-fed lean rats. On the other hand, HS intake in obese rats caused an increase in the cortical expression of ACE, a decrease in ACE2, AT(2)R, and MasR, and no changes in renin and AT(1)R. The cortical levels of ANG II increased by threefold in obese rats on HS compared with obese rats on normal salt (NS), which was not different than in lean rats. The HS intake elevated mean arterial pressure in obese rats (27 mmHg) more than in lean rats (16 mmHg). This study suggests that HS intake causes a pronounced increase in ANG II levels and a reduction in the expression of the ACE2-AT(2)R-MasR axis in the kidney cortex of obese rats. We conclude that such changes may lead to the potentially unopposed function of AT(1)R, with its various cellular and physiological roles, including the contribution to the pathogenesis of obesity-related hypertension.
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