ArticleJournal of acquired immune deficiency syndromes (1999)2012
Transmitted drug resistance and phylogenetic relationships among acute and early HIV-1-infected individuals in New York City.
Article in Journal of acquired immune deficiency syndromes (1999), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Global HIV-1 transmitted drug resistance in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial.HIV medicine · 2015Trial
- Acute HIV-1 Infection: Paradigm and Singularity.Viruses · 2025Review
- Factors Associated With Newly HIV Infection and Transmitted Drug Resistance Among Men Who Have Sex With Men in Harbin, P.R. China.Frontiers in public health · 2022Article
- Article
- Transmitted Drug Resistance in Antiretroviral Therapy-Naive Persons With Acute/Early/Primary HIV Infection: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2021Review
- Focus on recently developed assays for detection of resistance/sensitivity to reverse transcriptase inhibitors.Applied microbiology and biotechnology · 2018Review
- Prevalence of pretreatment HIV drug resistance in Cameroon following a nationally representative WHO survey.The Journal of antimicrobial chemotherapy · 2018Article
- Leveraging Phylogenetics to Understand HIV Transmission and Partner Notification Networks.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- Changes from 2000 to 2009 in the Prevalence of HIV-1 Containing Drug Resistance-Associated Mutations from Antiretroviral Therapy-Naive, HIV-1-Infected Patients in the United States.AIDS research and human retroviruses · 2018Article
- Article
- Newly Acquired Infection With Multidrug-Resistant HIV-1 in a Patient Adherent to Preexposure Prophylaxis.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Article
- The prevalence of drug resistance among treatment-naïve HIV-1-infected individuals in China during pre- and post- 2004.BMC infectious diseases · 2016Article
- Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Article
- Future of phylogeny in HIV prevention.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Transmitted human immunodeficiency virus-1 drug resistance in a cohort of men who have sex with men in Belo Horizonte, Brazil--1996-2012.Memorias do Instituto Oswaldo Cruz · 2013Article
- Phylogenetic inferences on HIV-1 transmission: implications for the design of prevention and treatment interventions.AIDS (London, England) · 2013Review
- Participation in research involving novel sampling and study designs to identify acute HIV-1 infection among minority men who have sex with men.AIDS care · 2013Article
- Transmitted drug resistance in patients with acute/recent HIV infection in Brazil.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundTransmitted drug resistance (TDR) is critical to managing HIV-1-infected individuals and being a public health concern. We report on TDR prevalence and include analyses of phylogenetic clustering of HIV-1 in a predominantly men who have sex with men cohort diagnosed during acute/recent HIV-1 infection in New York City.
methodsGenotypic resistance testing was conducted on plasma samples of 600 individuals with acute/recent HIV-1 infection (1995-2010). Sequences were used for resistance and phylogenetic analyses. Demographic and clinical data were abstracted from medical records. TDR was defined according to International AIDS Society-USA and Stanford HIV database guidelines. Phylogenetic and other analyses were conducted using PAUP*4.0 and SAS, respectively.
resultsThe mean duration since HIV-1 infection was 66.5 days. TDR prevalence was 14.3% and stably ranged between 10.8% and 21.6% (P(trend) = 0.42). Nucleoside reverse transcriptase inhibitors resistance declined from 15.5% to 2.7% over the study period (P(trend) = 0.005). M41L (3.7%), T215Y (4.0%), and K103N/S (4.7%) were the most common mutations. K103N/S prevalence increased from 1.9% to 8.0% between 1995 and 2010 (P(trend) = 0.04). Using a rigorous definition of clustering, 19.3% (112 of 581) of subtype B viral sequences cosegregated into transmission clusters and clusters increased over time. There were fewer and smaller transmission clusters than had been reported in a similar cohort in Montreal but similar to reports from elsewhere.
conclusionsTDR is stable in this cohort and remains a significant concern to both individual patient management and the public health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.