ArticleNeurosurgery2012
Seizure predictors and control after microsurgical resection of supratentorial arteriovenous malformations in 440 patients.
Article in Neurosurgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Complete seizure-free rates following interventional treatment of intracranial arteriovenous malformations: a systematic review and meta-analysis.Neurosurgical review · 2022Pooled it
- Rates and Predictors of Seizure Freedom With Vagus Nerve Stimulation for Intractable Epilepsy.Neurosurgery · 2016Pooled it
- Medical vs. invasive therapy in AVM-related epilepsy: Systematic review and meta-analysis.Neurology · 2016Pooled it
- Surgical outcomes of Spetzler-Martin grade III arteriovenous malformations in the multimodality era: a single centre retrospective cohort study.Neurosurgical review · 2025Article
- Outcomes of gamma knife treated large symptomatic arteriovenous malformations according to guidelines of Taiwan neurosurgical consensus.Radiation oncology (London, England) · 2025Article
- The Dynamics of Seizures After Microsurgical Treatment of Brain AVMs in Patients with Symptomatic Epilepsy: A Single-Center Experience over 10 Years.Medicina (Kaunas, Lithuania) · 2025Article
- Seizure presentation and incidence-associated factors in treated cerebral arteriovenous malformations: a secondary analysis of the MISTA consortium.Neurosurgical review · 2025Article
- Surgical Results with Low-Grade Arteriovenous Malformations : A Single Center 14-Year Experience.Journal of Korean Neurosurgical Society · 2024Article
- Residual brain AVMs after surgical resection: A literature review of causes and treatment considerations.World neurosurgery: X · 2024Review
- Natural History and Predictors for Hemorrhage in Supratentorial Brain Arteriovenous Malformations.Journal of clinical medicine · 2024Article
- Use of near infrared spectroscopy for the prediction of perioperative complications in patients undergoing elective microsurgical resection of cerebral arteriovenous malformations- a prospective observational trial (NIRSCAM trial).Journal of clinical monitoring and computing · 2024Observational
- Feasibility of awake craniotomy for brain arteriovenous malformations: A scoping review.World neurosurgery: X · 2024Article
- Treatment of Brain Arteriovenous Malformations.Advances and technical standards in neurosurgery · 2024Article
- Incidence and risk factors of epilepsy following brain arteriovenous malformation rupture in adult patients.Journal of neurology · 2022Article
- Benefits from Exclusion Treatment of Unruptured Brain Arteriovenous Malformations on Epilepsy in Adults.Clinical neuroradiology · 2022Observational
- Chinese guideline on the application of anti-seizure medications in the perioperative period of supratentorial craniocerebral surgery.Therapeutic advances in neurological disorders · 2022Review
- Classification of brain arteriovenous malformations located in motor-related areas based on location and anterior choroidal artery feeding.Stroke and vascular neurology · 2021Article
- Seizure predictors and outcome after Onyx embolization in patients with brain arteriovenous malformations.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2019Article
- Relief of epilepsy and headache and quality of life after microsurgical treatment of unruptured brain AVM-audit of a single-center series and comprehensive review of the literature.Neurosurgical review · 2017Article
- Factors associated with seizure occurrence and long-term seizure control in pediatric brain arteriovenous malformation: a retrospective analysis of 89 patients.BMC neurology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSeizures are a common symptom of supratentorial arteriovenous malformations (AVMs), and uncontrolled epilepsy can considerably reduce patient quality of life. Potential risk factors for epilepsy in patients with AVMs are poorly understood, and the importance of achieving freedom from seizures in their surgical treatment remains underappreciated.
objectiveTo characterize risks factors for preoperative seizures and factors associated with postoperative freedom from seizures in patients with surgically resected supratentorial AVMs.
methodsWe analyzed prospectively collected patient data for 440 patients who underwent microsurgical resection of supratentorial AVMs at our institution.
resultsAmong 440 patients with supratentorial AVMs, 130 (30%) experienced preoperative seizures, and 23 (18%) with seizures progressed to medically refractory epilepsy. Seizures were associated with a history of AVM hemorrhage (relative risk, 6.65; 95% confidence interval [CI], 3.81-11.6), male sex (relative risk, 2.07; 95% CI, 1.26-3.39), and frontotemporal lesion location (relative risk, 1.75; 95% CI, 1.05-2.93). After resection, 96% of patients had a modified Engel class I outcome, characterized by freedom from seizures (80%) or only 1 postoperative seizure (16%; mean follow-up, 20.7 ± 2.3 months). Comparable rates of postoperative seizures were seen in patients with (7%) or without (3%) preoperative seizures. AVMs with deep artery perforators were significantly associated with postoperative seizures (hazard ratio, 4.35; 95% CI, 1.61-11.7).
conclusionIn the microsurgical treatment of supratentorial AVMs, hemorrhage, male sex, and frontotemporal location are associated with higher rates of preoperative seizures, whereas deep artery perforators are associated with postoperative seizures. Achieving freedom from seizure is an important goal that can be achieved in the surgical treatment of AVMs because epilepsy can significantly diminish patient quality of life.
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