ArticleJournal of neurophysiology2012
AMPA receptor-dependent, light-evoked D-serine release acts on retinal ganglion cell NMDA receptors.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- d-amino acids: new functional insights.The FEBS journal · 2025Review
- Place cells in the claustrum remap under NMDA receptor control.The European journal of neuroscience · 2022Article
- Effects of D-serine treatment on outer retinal function.Experimental eye research · 2021Article
- Converging Evidence on D-Amino Acid Oxidase-Dependent Enhancement of Hippocampal Firing Activity and Passive Avoidance Learning in Rats.The international journal of neuropsychopharmacology · 2021Article
- TRPV1 Supports Axogenic Enhanced Excitability in Response to Neurodegenerative Stress.Frontiers in cellular neuroscience · 2020Article
- Extrasynaptic NMDA Receptors on Rod Pathway Amacrine Cells: Molecular Composition, Activation, and Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Structure, function, and allosteric modulation of NMDA receptors.The Journal of general physiology · 2018Review
- Axogenic mechanism enhances retinal ganglion cell excitability during early progression in glaucoma.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses.eLife · 2017Article
- Dynamic regulation of D-serine release in the vertebrate retina.The Journal of physiology · 2015Article
- The role of glia in stress: polyamines and brain disorders.The Psychiatric clinics of North America · 2014Review
- Retinal NMDA receptor function and expression are altered in a mouse lacking D-amino acid oxidase.Journal of neurophysiology · 2013Article
- Glycine transporter 1 modulates GABA release from amacrine cells by controlling occupancy of coagonist binding site of NMDA receptors.Journal of neurophysiology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
NMDA receptor (NMDAR) activation requires coincident binding of the excitatory neurotransmitter glutamate and a coagonist, either glycine or D-serine. Changes in NMDAR currents during neural transmission are typically attributed to glutamate release against a steady background of coagonist, excluding the possibility of coagonist release. AMPA receptor (AMPAR) stimulation evokes D-serine release, but it is unknown whether this is a physiological phenomenon capable of influencing synaptic responses. In this study, we utilized the intact retina to determine whether light-evoked synaptic activity in retinal ganglion cells (RGCs) is shaped by a dynamic pool of coagonist. The application of AMPAR antagonist abolished light-evoked NMDAR currents, which were rescued by adding coagonist to the bath. When NMDA was globally applied to RGCs via bath or picospritzing, the coagonist occupancy was also dependent on AMPARs but to a lesser extent than that observed during light responses, suggesting a difference in extrasynaptic coagonist regulation. By saturating the glutamate binding site of NMDARs, we were able to detect released coagonist reaching RGCs during light-evoked responses. Mutant mice lacking the d-serine-synthesizing enzyme serine racemase were deficient in coagonist release. Coagonist release in wild-type retinas was notably greater in ON than in OFF responses and depended on AMPARs. These findings suggest activity-dependent modulation of coagonist availability, particularly D-serine, and may add an extra dimension to NMDAR coincidence detection in the retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.