SynthesisJournal of neurology2012
Tremor-spectrum in spinocerebellar ataxia type 3.
Synthesis in Journal of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- IMovement disorders clinical practice · 2024Pooled it
- Slow Orthostatic Tremor: Review of the Current Evidence.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Pooled it
- Tremulous SCA3: The Complex Connection between the Cerebellum and Basal Ganglia.Cerebellum (London, England) · 2025Article
- Three hertz orthostatic tremor as "red flag sign" candidate for multiple system atrophy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Early-onset familial essential tremor is associated with nucleotide expansions of spinocerebellar ataxia in China.Molecular biology reports · 2024Article
- Tremor in Spinocerebellar Ataxia: A Scoping Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Movement disorders and neuropathies: overlaps and mimics in clinical practice.Journal of neurology · 2022Review
- 3-Hz Postural Tremor in MSA-C and SCA: Revisiting an Old but Underestimated Cerebellar Sign by Posturography.Cerebellum (London, England) · 2021Article
- Ataxia Prevalence in Primary Orthostatic Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Article
- Essential Tremor Within the Broader Context of Other Forms of Cerebellar Degeneration.Cerebellum (London, England) · 2020Review
- The impact of ethnicity on the clinical presentations of spinocerebellar ataxia type 3.Parkinsonism & related disorders · 2020Article
- Revisiting the Clinical Phenomenology of "Cerebellar Tremor": Beyond the Intention Tremor.Cerebellum (London, England) · 2019Review
- Fully automated leg tracking of Drosophila neurodegeneration models reveals distinct conserved movement signatures.PLoS biology · 2019Article
- Postural Tremor and Ataxia Progression in Spinocerebellar Ataxias.Tremor and other hyperkinetic movements (New York, N.Y.) · 2017Article
- Altered striatal endocannabinoid signaling in a transgenic mouse model of spinocerebellar ataxia type-3.PloS one · 2017Article
- Movement Disorders in Autosomal Dominant Cerebellar Ataxias: A Systematic Review.Movement disorders clinical practice · 2014Review
- Shaking on Standing: A Critical Review.Movement disorders clinical practice · 2014Review
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinocerebellar ataxia type 3 (SCA3) can be present with a combination of cerebellar, neuropathic, pyramidal, or extrapyramidal symptoms. Tremor is a classical but not frequent manifestation of SCA3 and there is a lack of detailed knowledge regarding its origin. To study the clinical and electrophysiological characteristics of tremor in SCA3 patients, the authors conducted a case series of 72 SCA3 patients. Clinical characteristics of tremor and associated signs, response to treatments, follow-up, and genetic results were collected. Electrophysiological study including polymyographic recording was possible in 4/6 patients and DaTSCAN in 2/6. The authors also performed a systematic review of SCA3 cases with tremor (n = 36) reported previously in the literature. We identified two different tremor-types in 6/72 patients with SCA3 mutations, a "fast" (6.5-8 Hz) action, postural or tremor in orthostatism (initial symptom), which became slower over time with associated parkinsonism with a follow-up of 10 years and a "slow" rest, action and intention tremor (3-4 Hz) with distal and proximal component (including axial tremor in orthostatism). Total improvement of limbs and tremor in orthostatism was obtained with levodopa with occurrence of fluctuations/dyskinesia. Partial benefit was observed when additional signs were present (myoclunus/dystonia). The differences in tremor subtypes in SCA3 may be related to various combinations of mild to severe dysfunctions of the cerebello-thalamo-cortical loop and the nigro-striatal dopaminergic pathway.
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Registered trials
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