Evidence map›Paper›PMID 22591967›Full record

ArticleThe Journal of urology2012

Associations of commonly used medications with urinary incontinence in a community based sample.

Susan A Hall, May Yang, Margaret A Gates, William D Steers, Sharon L Tennstedt, John B McKinlay

Open access · greenAbstract readComparative Study
In one paragraph

Article in The Journal of urology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Role of local angiotensin II signaling in bladder function.American journal of physiology. Renal physiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Susan A HallNew England Research Institutes, Watertown, Massachusetts 02472, USA.
May Yang
Margaret A Gates
William D Steers
Sharon L Tennstedt
John B McKinlay
New England Research Institutes · USUniversity of Virginia · US

Funding

Trajectories of Urologic Disease: Follow-up of BACHU01DK056842 · NIDDK · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MCKINLAY, JOHN B · 2001 to 2011
$15.7M
Trajectories of Urologic Disease: Follow-up of BACHR01DK056842 · NIDDK · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MCKINLAY, JOHN B · 2007 to 2007
$1.2M
Pharmacoepidemiology of Urologic SymptomsR21DK082652 · NIDDK · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI HALL, SUSAN AUDREY · 2009 to 2010
$384k
NIDDK NIH HHS R01 DK056842NIDDK NIH HHS R21 DK082652NIDDK NIH HHS R21DK082652NIDDK NIH HHS U01 DK056842
6 · The paper itself

Abstract

purposeWe examined the association between the use of medications and the prevalence of urinary incontinence in gender specific analyses of a community based, representative sample. MATERIALS AND

methodsA population based epidemiological study was conducted of 5,503 men and women 30 to 79 years old residing in Boston, Massachusetts (baseline data collected from 2002 to 2005). Urological symptoms were ascertained in a 2-hour, in person interview. Urinary incontinence was defined as urine leakage occurring weekly or more often during the last year. Medications used in the last month were considered current use. Associations of 20+ medications and prevalent urinary incontinence were examined using multivariate logistic regression (ORs and 95% CIs) with adjustments for known urinary incontinence risk factors.

resultsThe prevalence of urinary incontinence in the analysis sample was 9.0% in women and 4.6% in men. For women the prevalence was highest among users of certain antihistamines (28.4%) and angiotensin II receptor blockers (22.9%). For men the prevalence was highest among angiotensin II receptor blocker (22.2%) and loop diuretic (19.1%) users. After final multivariate adjustment there were significant positive associations for certain antihistamines, beta receptor agonists, angiotensin II receptor blockers and estrogens with urinary incontinence in women (all ORs greater than 1.7), and a borderline significant association for anticonvulsants (OR 1.75; 95% CI 1.00, 3.07). Among men only anticonvulsants were associated with urinary incontinence after final adjustments (OR 2.50; 95% CI 1.24, 5.03), although angiotensin II receptor blockers showed an adjusted association of borderline significance (OR 2.21; 95% CI 0.96, 5.10).

conclusionsAlthough a cross-sectional analysis cannot determine causality, our analysis suggests certain medications should be further examined in longitudinal analyses of risk to determine their influence on urological symptoms.

Indexed as

Adrenergic beta-AgonistsAdultAgedAngiotensin Receptor AntagonistsAnticonvulsantsCross-Sectional StudiesFemaleHistamine AntagonistsHumansMaleMassachusettsMiddle AgedPopulation SurveillancePrevalencePrognosisRetrospective StudiesAdrenergic beta-AgonistsAngiotensin Receptor AntagonistsAnticonvulsantsHistamine AntagonistsSodium Potassium Chloride Symporter Inhibitors

Identifiers

PMID22591967
PMCPMC3523747
OpenAlexW1968357545

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.