Trial reportAlcoholism, clinical and experimental research2012
Differential effects of moderate alcohol consumption on performance among older and younger adults.
Trial report in Alcoholism, clinical and experimental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Brief report: Aging adult utilization of an mHealth intervention for problem drinking.Frontiers in public health · 2024Trial
- Acute effect of alcohol on working memory updating.Addiction (Abingdon, England) · 2021Trial
- Working Memory Performance Following Acute Alcohol: Replication and Extension of Dose by Age Interactions.Journal of studies on alcohol and drugs · 2019Trial
- Effects of Age and Acute Moderate Alcohol Administration on Neurophysiology During Simulated Driving.Alcoholism, clinical and experimental research · 2016Trial
- Alcohol Doesn't Always Compromise Cognitive Function: Exploring Moderate Doses in Young Adults.Journal of studies on alcohol and drugs · 2015Trial
- The effects of acute alcohol on psychomotor, set-shifting, and working memory performance in older men and women.Alcohol (Fayetteville, N.Y.) · 2015Trial
- Testing the initial efficacy of a mailed screening and brief feedback intervention to reduce at-risk drinking in middle-aged and older adults: the comorbidity alcohol risk evaluation study.Journal of the American Geriatrics Society · 2015Trial
- Neurophysiological correlates of moderate alcohol consumption in older and younger social drinkers.Alcoholism, clinical and experimental research · 2013Trial
- Bidirectional relationships between pain and alcohol use among older adults: a scoping review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Linking alcohol use to Alzheimer's disease: Interactions with aging and APOE along immune pathways.Medical research archives · 2024Article
- Age as a moderator of motivational interviewing and nondirective client-centered psychotherapy for alcohol use disorder: An exploratory study.Alcohol, clinical & experimental research · 2023Article
- Alcohol Use Disorder and Associated Factors Among Elderly in Ethiopia.Substance abuse : research and treatment · 2023Article
- A Community-Based Exploratory Cross-Sectional Study of Elder Abuse Perpetration or Victimization Among Elders in Ethiopia, 2022.Clinical interventions in aging · 2022Article
- The Effects of Cannabis Use on Cognitive Function in Healthy Aging: A Systematic Scoping Review.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2021Article
- Prevalence and Predictors of Neurocognitive Impairment in Ethiopian Population Living with HIV.HIV/AIDS (Auckland, N.Z.) · 2020Article
- Clarifying the neurobehavioral sequelae of moderate drinking lifestyles and acute alcohol effects with aging.International review of neurobiology · 2019Review
- Social networks and alcohol use among older adults: a comparison with middle-aged adults.Aging & mental health · 2018Article
- Effects of acute alcohol and driving complexity in older and younger adults.Psychopharmacology · 2018Article
- Disruption of sensory gating by moderate alcohol doses.Psychopharmacology · 2014Article
- Age-related effects of alcohol from adolescent, adult, and aged populations using human and animal models.Alcoholism, clinical and experimental research · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundStudies exploring differential effects of acute alcohol consumption on younger and older adults are lacking within the field of alcohol research, especially those using moderate doses. Previous studies addressing this question have tended to use complex behavioral tasks too broad to isolate specific neurocognitive processes affected by both alcohol and aging. Compromises in cognitive efficiency (i.e., the ability to respond both quickly and accurately) have previously been identified in both elderly and acutely intoxicated individuals.
methodsThe present study employed a visual-spatial, 2-choice reaction time (RT) task to evaluate the interactive effects of aging and alcohol on cognitive efficiency. Our primary outcome measure was an efficiency ratio derived from each participant's response accuracy (ACC) and mean RT (%correct/RT). Younger (25 to 35; n = 22) and older (55 to 74; n = 37) participants were randomly assigned to receive either a placebo or moderate alcohol dose intended to produce a peak breath alcohol concentration of 0.04%. Participants performed the task at peak alcohol levels.
resultsA significant interaction between age group and dose assignment was observed, F(3, 55) = 4.86, p = 0.03, for the efficiency ratio. Younger participants who received alcohol performed significantly better than did their older counterparts regardless of alcohol condition and despite no differences in performance between the 2 age groups in the placebo condition. Additional correlation analyses between ACC and RT suggested that moderately intoxicated older adults become more accurate as response times increase. This relationship was not observed in older adults in the placebo condition.
conclusionsThese data suggest that healthy individuals exhibit a differential susceptibility to the effects of alcohol depending on their age. Unfortunately, because of the presumed safety of moderate alcohol doses and a lack of studies investigating the interactive effects of acute alcohol consumption and aging, most individuals are unlikely to be aware of this relationship between alcohol consumption and age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.