ArticleChemical research in toxicology2012
Cys34 adducts of reactive oxygen species in human serum albumin.
Article in Chemical research in toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 59 citations in OpenAlex.
- Cord Blood Adductomic Profiling Provides Preliminary Insights on Perinatal Smoking Exposure: A Pilot Analysis.Antioxidants (Basel, Switzerland) · 2026Article
- Use of Human Serum Albumin CysAntioxidants (Basel, Switzerland) · 2026Review
- The Unique Utility of Newborn Dried Blood Spots for Driving Discovery in Childhood Cancer Research.Clinical chemistry · 2025Review
- Synergistic Genotoxic Effects of Gamma Rays and UVB Radiation on Human Blood.Antioxidants (Basel, Switzerland) · 2025Article
- Albumin as a natural and moldable biomaterial for biomimetic drug delivery applications.International journal of pharmaceutics · 2025Review
- Effects of propolis intake on endurance exercise and molecular signaling related to inflammation and oxidative stress.Frontiers in nutrition · 2025Review
- Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia.Antioxidants (Basel, Switzerland) · 2024Article
- Albumin Is a Component of the Esterase Status of Human Blood Plasma.International journal of molecular sciences · 2023Article
- New Synthetic Quinoline (Qui) Derivatives as Novel Antioxidants and Potential HSA's Antioxidant Activity Modulators-Spectroscopic Studies.Molecules (Basel, Switzerland) · 2022Article
- Esterase Activity of Serum Albumin Studied byInternational journal of molecular sciences · 2021Article
- Applications of Adductomics in Chemically Induced Adverse Outcomes and Major Emphasis on DNA Adductomics: A Pathbreaking Tool in Biomedical Research.International journal of molecular sciences · 2021Review
- Metabolism and biomarkers of heterocyclic aromatic amines in humans.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Review
- Biomonitoring of Ambient Outdoor Air Pollutant Exposure in Humans Using Targeted Serum Albumin Adductomics.Chemical research in toxicology · 2021Article
- Serum Albumin Redox States: More Than Oxidative Stress Biomarker.Antioxidants (Basel, Switzerland) · 2021Review
- Human Serum Albumin Cys34 Adducts in Newborn Dried Blood Spots: Associations With Air Pollution Exposure During Pregnancy.Frontiers in public health · 2021Article
- The Universal Soldier: Enzymatic and Non-Enzymatic Antioxidant Functions of Serum Albumin.Antioxidants (Basel, Switzerland) · 2020Review
- Untargeted adductomics of newborn dried blood spots identifies modifications to human serum albumin associated with childhood leukemia.Leukemia research · 2020Article
- Cys34 Adductomics Links Colorectal Cancer with the Gut Microbiota and Redox Biology.Cancer research · 2019Article
- Review
- Untargeted adductomics of Cys34 modifications to human serum albumin in newborn dried blood spots.Analytical and bioanalytical chemistry · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Long-term exposures to reactive oxygen species (ROS) have been linked to scores of chronic diseases. This has motivated interest in oxidation products of the only free cysteine residue (Cys34) of human serum albumin (HSA) as possible biomarkers of ROS exposure. However, Cys34 oxidation products have not been detected in human serum or plasma. Using liquid chromatography-high resolution tandem mass spectrometry, we report accurate masses and molecular compositions of Cys34 oxidation products in the 2432 Da peptide resulting from tryptic digestion of HSA. Peptides containing the expected sulfinic (Cys-SO(2)H) and sulfonic (Cys-SO(3)H) acids, as well as an adduct representing addition of one oxygen atom and loss of two hydrogen atoms, were detected in four archived samples of human plasma and one fresh sample of human serum. We speculate that this latter adduct is a sulfinamide formed by intramolecular reaction between either the Cys34 sulfenic acid (Cys-SOH) or sulfinic acid (Cys-SO(2)H) and the adjacent glutamine residue (Gln33). All three Cys34 adducts were measured in the five human samples with levels decreasing in the order sulfinic acid > (proposed) sulfinamide > sulfonic acid. Parallel measurements of a negative control detected only small amounts of the Cys34 sulfonic acid and the (proposed) sulfinamide and did not detect the sulfinic acid.
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Registered trials
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